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100-63-0 - Phenylhydrazine, 97% - A11246 - Alfa Aesar

A11246 Phenylhydrazine, 97%

CAS 번호
100-63-0
동의어

사이즈 가격 ($) 수량 재고 여부
50g 17.70
250g 60.00
장바구니에 추가 대량 견적에 추가 항목 보기

Phenylhydrazine, 97%

MDL
MFCD00007573
EINECS
202-873-5

화학적 특성

화학식
C6H8N2
화학 식량
108.14
융점
18-20°
비등점
238-241°
인화점
88°(190°F)
밀도
1.099
굴절률
1.6065
감도
Air & Light Sensitive
용해도
Soluble in dilute acids.

용도

Phenyl hydrazine is involved in Fischer indole synthesis to prepare indoles, which find application as intermediates in the pharmaceuticals particularly for the tryptamine drug. In analytical chemistry, it is used to differentiate and separate sugars by forming phenyhydrazones. It is used as an N-protecting reagent and for cleavage of phthaloyl group.

참고

Air and light sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.

참조 문헌

Derivatizing agent for the conversion of carbonyl compounds to their phenylhydrazones best known as intermediates in the Fischer indole synthesis, by cyclization under acidic conditions with loss of ammonia. The classical reagent is anhydrous ZnCl2: Org. Synth. Coll., 3, 725 (1976). For reviews, see: Chem. Rev., 63, 373 (1963); 69, 227 (1969); Tetrahedron, 36, 161 (1980); Org. Prep. Proced. Int., 25, 609 (1993). Milder cyclization conditions are sometimes effective, e.g.: dilute H2SO4: J. Org. Chem., 59, 3738 (1994); PCl3: J. Chem. Soc., Chem. Commun., 563 (1981); Tetrahedron, 41, 4615 (1985). Cyclohexanone phenylhydrazone gives tetrahydrocarbazole on heating in acetic acid: Org. Synth. Coll., 4, 884 (1963).

Methods used for the cleavage of phenylhydrazones include exchange by refluxing with acetone: J. Org. Chem., 40, 3302 (1975), or oxidative cleavage by Fe(NO3)3 on a clay support: Synthesis, 439 (1985).

Wang, L.; Wang, P.; Liu, Y.; Zheng, L.; Sun, Q.; Qiu, S.; Liu, C. Effects of phenylhydrazine-4-sulfonic acid on the reduction of GO and preparation of hydrophilic graphene with broad pH stability and antioxidant activity. RSC Adv. 2015, 5 (48), 38696-38705.

Gein, V. L.; Mar’yasov, M. A. Reactions of 5-aryl-4-(hetaren-2-ylcarbonyl)-3-hydroxy-1-(1, 3-thiazol-2-yl)-2, 5-dihydro-1H-pyrrol-2-ones with hydrazine, phenylhydrazine, and hydroxylamine. Russ. J. Org. Chem. 2015, 51 (1), 110-115.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227-H301-H311-H331-H315-H319-H317-H341-H350-H372

Combustible liquid. Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause cancer. Causes damage to organs through prolonged or repeated exposure.

주의 설명서: P210u-P260-P301+P310a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,7293
바일슈타인
606080
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2928.00
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
MV8925000

권장

최근에 본 것

화학물질

화학물질

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