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402-31-3 - 1,3-Bis(trifluoromethyl)benzene, 98+% - alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-m-xylene - A11360 - Alfa Aesar

A11360 1,3-Bis(trifluoromethyl)benzene, 98+%

CAS 번호
402-31-3
동의어
alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-m-xylene

사이즈 가격 ($) 수량 재고 여부
50g 39.80
250g 135.00
1000g 422.00
장바구니에 추가 대량 견적에 추가 항목 보기

1,3-Bis(trifluoromethyl)benzene, 98+%

MDL
MFCD00000392
EINECS
206-939-4

화학적 특성

화학식
C8H4F6
화학 식량
214.11
융점
-35°
비등점
115-117°
인화점
26°(78°F)
밀도
1.378
굴절률
1.3790
용해도
Insoluble in water. Soluble in alcohol, ether, benzene.

용도

1,3-Bis(trifluoromethyl)benzene undergoes regioselective metalation and subsequent carboxylation at position 2 to give 2,6-bis(trifluoromethyl)benzoic acid. a convenient, selective synthesis of bis[2,4-bis(trifluoromethyl)phenyl]phosphane derivatives with 1,3-bis(trifluoromethyl)benzene as starting material.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

참조 문헌

Aeberli P,; Houlihan WJ. The Metalation of 1, 3-Bis (trifluoromethyl) benzene by n butyllithium.. J. Organomet. Chem. 1974, 64 (3), 321-25.

Berthold Hoge Dr.,; Boris Kurscheid,; Sebastian Peuker,; Wieland Tyrra,; Hendrik T. M. Fischer. A Convenient, Selective Synthesis of Bis[2,4-bis(trifluoromethyl)phenyl]phosphane Derivatives Starting from 1,3-Bis(trifluoromethyl)benzene† . Zeitschrift für anorganische und allgemeine Chemie. 2007, 633 (10) ,679-1685 pg no.

Metallation with n-BuLi in diethyl ether is unselective, giving, on quenching with CO2, a mixture of 2,4- and 2,6-bis(trifluoromethyl)benzoic acids: J. Organomet. Chem., 67, 321 (1974). The superbasic n-BuLi/KO-t-Bu combination leads to almost exclusive 2-metallation, allowing the 2,6-bis(trifluoromethyl) acid to be isolated in 78% yield. In contrast, a combination of sec-BuLi and N,N,N',N',N'-pentamethyldiethylenetriamine leads to the 2,4-bis(trifluoromethyl) acid as the main product: Synlett, 747 (1990).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P210-P260-P280g-P305+P351+P338

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

기타 참조

바일슈타인
2052589
위험 등급
3
포장 그룹
III
통합 관세 코드
2903.99
TSCA(독성물질규제법)"
Yes

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