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89-00-9 - Pyridine-2,3-dicarboxylic acid, 99% - Quinolinic acid - A11414 - Alfa Aesar

A11414 Pyridine-2,3-dicarboxylic acid, 99%

CAS 번호
89-00-9
동의어
Quinolinic acid

사이즈 가격 ($) 수량 재고 여부
25g 22.20
100g 57.40
장바구니에 추가 대량 견적에 추가 항목 보기

Pyridine-2,3-dicarboxylic acid, 99%

MDL
MFCD00006295
EINECS
201-874-8

화학적 특성

화학식
C7H5NO4
화학 식량
167.12
융점
ca 188° dec.
용해도
Soluble in water (partly), alkalies, dilute aqueous base, DMSO, and alcohol (slightly).

용도

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an “excitotoxic” metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

참조 문헌

MF Beal,; RJ Ferrante,; KJ Swartz,; NW Kowall. Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. The Journal of Neuroscience,. 1991, 11(6), 1649-1659.

Dr Melvyn P. Heyes PhD,; Bruce J. Brew MD,; Alex Martin PhD,; Richard W. Price MD,; Andres M. Salazar MD.Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status. Annals of Neurology. 1991 , 29 (2),202-209.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,8073
바일슈타인
137110
통합 관세 코드
2933.39
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
US7967250

권장

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    Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water
  • 33369

    Sodium hypochlorite, 11-15% available chlorine

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