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105-56-6 - Ethyl cyanoacetate, 98+% - Cyanoacetic acid ethyl ester - A11498 - Alfa Aesar

A11498 Ethyl cyanoacetate, 98+%

CAS 번호
105-56-6
동의어
Cyanoacetic acid ethyl ester

사이즈 가격 ($) 수량 재고 여부
500g 43.20
2500g 169.00
장바구니에 추가 대량 견적에 추가 항목 보기

Ethyl cyanoacetate, 98+%

MDL
MFCD00001940
EINECS
203-309-0

화학적 특성

화학식
C5H7NO2
화학 식량
113.12
융점
-23°
비등점
208-210°
인화점
109°(228°F)
밀도
1.063
굴절률
1.4180
용해도
It is slightly soluble in water. Mostly soluble in organic solvents such as chloroform, ethyl acetate.

용도

Cyanoacetate is a building block for the synthesis of heterocycles and are are used as drugs. It is also used as Pharmaceutical intermediates, or Oil soluble couplers of film raw material . It is also used as a reagent in labelled pyrimidine and purine synthesis. It is used as an intermediate of fine chemicals such as medicine and dyestuff.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials strong acids, strong bases, strong oxidizing agents, strong reducing agents.

참조 문헌

Jose A. Cabello.; Juan M. Campelo.; Angel Garcia.; Diego Luna.; Jose M. Marinas. Knoevenagel condensation in the heterogeneous phase using aluminum phosphate-aluminum oxide as a new catalyst. J. Org. Chem. 1984, 49, (26), 5195-5197.

Rajendra K. Singh.; Samuel Danishefsky. Preparation of activated cyclopropanes by phase transfer alkylation. J. Org. Chem. 1975, 40, (20), 2969-2970.

Stereoselective alkylation of the active methylene has been accomplished under particularly mild conditions with secondary alkyl mesylates in the presence of CsF in DMF; complete inversion occurs at the secondary alkyl carbon: J. Org. Chem., 60, 2627 (1995).

Arylation by aryl iodides is promoted by copper(I) iodide: Synthesis, 67 (1983); J. Org. Chem., 58, 7606 (1993); or trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491: Synthesis, 506 (1985).

For examples of Knoevenagel condensations of cyanoacetic esters with carbonyl compounds, see: Org. Synth. Coll., 3, 385, 399 (1955); 4, 93, 463 (1963); review: Org. React., 15, 204 (1967). Knoevenagel condensation with aromatic aldehydes has also been carried out under acidic conditions, for example, good yields have been obtained with ZnCl2: Tetrahedron Lett., 32, 5821 (1991).

For use in the synthesis of pyrrole derivatives, see p-Toluenesulfonyl­methyl­ isocyanide, A14312.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,3786
바일슈타인
605871
통합 관세 코드
2926.90
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
AG4110000

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