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7087-68-5 - N-Ethyldiisopropylamine, 99% - DIEA - N,N-Diisopropylethylamine - A11801 - Alfa Aesar

A11801 N-Ethyldiisopropylamine, 99%

CAS 번호
7087-68-5
동의어
DIEA
N,N-Diisopropylethylamine

사이즈 가격 ($) 수량 재고 여부
100ml 33.40
500ml 108.00
2500ml 393.00
장바구니에 추가 대량 견적에 추가 항목 보기

N-Ethyldiisopropylamine, 99%

MDL
MFCD00008868
EINECS
230-392-0

화학적 특성

화학식
C8H19N
화학 식량
129.25
융점
-46°
비등점
126-127°
인화점
8°(46°F)
밀도
0.747
굴절률
1.4135
용해도
Miscible with water and ethanol.

용도

N-Ethyldiisopropylamine is used to make or formulate industrial products. It is also used in organic chemistry as a base. It acts as a selective reagent in the alkylation of secondary amines to tertiary amines by alkyl halides. It reacts with monoactivated Michael acceptors to afford symmetrical sulfones. Further, it is used to prepare heterocyclic compound, sscorpionine by a reaction with disulfur dichloride using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a catalyst.

참고

Incompatible with acids, acid chlorides, acid anhydrides, carbon dioxide, copper, brass, rubber, oxidizing agents, nitrates, peroxides, aldehydes and metals.

참조 문헌

Hindered non-nucleophilic base with high proton affinity: Chem. Ber., 91, 380 (1958).

For use in the introduction of TBDMS protecting groups, see tert-Butyl­dimethyl­chlorosilane, A13064 . Used in preparation of silyl enol ethers from both aldehydes and ketones: Helv. Chim. Acta, 60, 181 (1977).

Useful base in peptide coupling reactions: J. Am. Chem. Soc., 91, 6488 (1969). See Appendix 6.

Has been recommended as a base for the Horner-Wadsworth-Emmons olefination reaction, where the reagents contain groups sensitive to base-catalyzed epimerization or condensation. The reaction is carried out in the presence of LiCl, and gives high (E):(Z) ratios: Tetrahedron Lett., 25, 2183 (1984).

Vembu, S.; Pazhamalai, S.; Gopalakrishnan, M. Potential antibacterial activity of triazine dendrimer: Synthesis and controllable drug release properties. Bioorg. Med. Chem. 2015, 23 (15), 4561-4566.

Manandhar, Y.; Bahadur, K. C. T.; Wang, W.; Uzawa, T.; Aigaki, T.; Ito, Y. In vitro selection of a peptide aptamer that changes fluorescence in response to verotoxin. Biotechnol. Lett 2015, 37 (3), 619-625.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H225-H302-H331-H318

Highly flammable liquid and vapour. Harmful if swallowed. Toxic if inhaled. Causes serious eye damage.

주의 설명서: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
605301
위험 등급
6.1
포장 그룹
I
통합 관세 코드
2921.19
TSCA(독성물질규제법)"
Yes

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