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70-34-8 - 1-Fluoro-2,4-dinitrobenzene, 99% - 2,4-Dinitrofluorobenzene - Sanger's Reagent - A11871 - Alfa Aesar

A11871 1-Fluoro-2,4-dinitrobenzene, 99%

CAS 번호
70-34-8
동의어
2,4-Dinitrofluorobenzene
Sanger's Reagent

사이즈 가격 ($) 수량 재고 여부
5g 26.60
25g 69.60
100g 186.00
장바구니에 추가 대량 견적에 추가 항목 보기

1-Fluoro-2,4-dinitrobenzene, 99%

MDL
MFCD00007056
EINECS
200-734-3

화학적 특성

화학식
C6H3FN2O4
화학 식량
186.10
융점
24-30°
비등점
296°
인화점
>110°(230°F)
밀도
1.482
굴절률
1.5690
용해도
Soluble in chloroform, benzene, ether and propylene glycol.

용도

1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. It reacts with amino group of amino acids to yield dinitrophenyl-amino acids. It is also used in chromatographic methods. Further, it acts as an alkylating agent used in elucidating amino acid sequence in proteins.

참고

Moisture sensitive. Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

참조 문헌

The activated fluoro-substituent is readily displaced by nucleophiles under mild conditions. The anomeric center of a carbohydrate has been protected as the 2,4-dinitrophenyl ether in the presence of DABCO in DMF: Rec. Trav. Chim., 99, 355 (1980).

Used for labelling terminal amino acids in peptides: Biochem. J., 45, 563 (1949); Biochemistry, 20, 512 (1981).

Has been used as a means of protection for the thiol group. The resulting thioether can be cleaved quantitatively with 2-mercaptoethanol: Biochem. Biophys. Res. Commun., 29, 178 (1967).

Can also be used for the masking of the imidazole ring in histidine as the 2,4-dinitrophenyl derivative during peptide synthesis, introduced in the presence of, e.g. K2CO3: Biochem. Biophys. Acta., 82, 412 (1964). The group can be cleaved by treatment with thioglycolic acid, mercaptoethanol, dithiothreitol or thiophenol: Biochem. Biophys. Res. Commun., 29, 178 (1967); Biochemistry, 9, 5122 (1970). The electron withdrawing character of the group has been shown to reduce racemization promoted by the imidazole function: J. Biol. Chem., 247, 4768 (1972). See Appendix 6.

Harifi-Mood, A. R.; Faramarzi, F.; Mehrabi, Y. Investigation of solvent effects on the reaction of 1-fluoro-2,4-dinitrobenzene with aniline in molecular-molecular and ionic liquid-molecular solvent mixtures. Prog. React. Kinet. Mec. 2015, 40 (1), 35-47.

Jalalizadeh, H.; Raei, M.; Tafti, R. F.; Farsam, H.; Kebriaeezadeh, A.; Souri, E. A Stability-Indicating HPLC Method for the Determination of Memantine Hydrochloride in Dosage Forms through Derivatization with 1-Fluoro-2,4-dinitrobenzene. Sci. Pharm. 2014, 82 (2), 265-279.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H301-H311-H331-H315-H318-H317-H341

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye damage. May cause an allergic skin reaction. Suspected of causing genetic defects.

주의 설명서: P201-P261-P301+P310a-P305+P351+P338-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,4172
바일슈타인
398632
위험 등급
6.1
포장 그룹
III
통합 관세 코드
2904.99
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
CZ7800000

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