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Isopropyl cyanoacetate was used in the synthesis of 3-substituted coumarins by undergoing Knöevenagel reactions with aldehydes and ketones.
Kohei Yamashita; Takanori Tanaka; Masahiko Hayashi. Use of isopropyl alcohol as a solvent in Ti(O-i-Pr)4-catalyzed Knöevenagel reactions. Tetrahedron,2005, 61(33), 7981-7985.
Chan Hyuk Kim; Ki Po Jang; Soo Young Choi; Young Keun Chung; and Eun Lee . A Carbonyl Ylide Cycloaddition Approach to Platensimycin. Angewandte Chemie International Edition,2008, 47(47), 4009-4011.
해저드 설명서 (EU): H227-H303-H315-H319-H335
Combustible liquid. May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
주의 설명서: P210u-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.