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300-87-8 - 3,5-Dimethylisoxazole, 99% - A12217 - Alfa Aesar

A12217 3,5-Dimethylisoxazole, 99%

CAS 번호
300-87-8
동의어

사이즈 가격 ($) 수량 재고 여부
25g 42.00
100g 129.00
장바구니에 추가 대량 견적에 추가 항목 보기

3,5-Dimethylisoxazole, 99%

MDL
MFCD00003156
EINECS
206-100-2

화학적 특성

화학식
C5H7NO
화학 식량
97.12
융점
-14°
비등점
142-144°
인화점
31°(87°F)
밀도
0.992
굴절률
1.4415
용해도
Insoluble in water.

용도

The optimization of 3,5-dimethylisoxazole derivatives to develop potent inhibitors of the BET (bromodomain and extra terminal domain) bromodomain family with good ligand efficiency. It has hypoglycemic activity.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

참조 문헌

Hewings DS; Fedorov O; Filippakopoulos P.; Martin S.; Picaud S.; Tumber A.; Wells C.; Olcina MM.; Freeman K.; Gill A.; Ritchie AJ.; Sheppard DW.; Russell AJ.; Hammond EM; Knapp S; Brennan PE; Conway SJ.Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem. 2013, 56 (8), 3217-27.

William E. Dulin; George C. Gerritsen. Hypoglycemic Activity of 3,5 Dimethylisoxazole. Exp Biol Med. 1963, 113 (3), 683-685.

Lithiation occurs first at the 5-methyl group. Subsequent reaction with electrophiles can be followed by further lithiation of the 3-methyl, providing a route to substituted isoxazoles, and also to 1,3-diketones by acid hydrolysis or ß-aminoketones by hydrogenolysis: Tetrahedron Lett., 22, 3699 (1981):

Review: Reaction of 3,5-dimethylisoxazole with some electrophiles: Heterocycles, 6, 805 (1977).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H226

Flammable liquid and vapour.

주의 설명서: P210-P280a-P240-P241-P303+P361+P353-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
106324
위험 등급
3
포장 그룹
III
통합 관세 코드
2934.99
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
NY2774200

권장

  • 11034

    Palladium(II) chloride, 99.9% (metals basis), Pd 59.0% min

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