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110-89-4 - Piperidine, 99% - A12442 - Alfa Aesar

A12442 Piperidine, 99%

CAS 번호
110-89-4
동의어

사이즈 가격 ($) 수량 재고 여부
100ml 23.40
500ml 53.80
2500ml 185.00
장바구니에 추가 대량 견적에 추가 항목 보기

Piperidine, 99%

MDL
MFCD00005979
EINECS
203-813-0

화학적 특성

화학식
C5H11N
화학 식량
85.15
융점
-11°
비등점
105-106°
인화점
3°(37°F)
밀도
0.862
굴절률
1.4520
감도
Air Sensitive
용해도
Miscible with ethanol, water,ethyl ether, acetone, benzene and chloroform

용도

Extensively finds applications as a base, a nucleophile and a solvent. Used for the production of dipiperidinyl dithiuram tetrasulfide, which is used as a rubber vulcanization accelerator. It is commonly used in solid phase peptide synthesis (F-MOC Chemistry) and in chemical degradation reactions (sequencing of DNA). Used in making rubber, curing epoxy resins and in fine chemicals, and pharmaceuticals.

참고

The piperidine skeleton is present in several naturally occuring alkaloids, such as piperine, solenopsin, coniine, etc., and in a wide variety of pharmaceuticals, such as SSRI (Selective Serotonin Reuptake Inhibitors), Vasodilators, SERM (Selective Estrogen Receptor Modulators), Neuroleptics (Antipsychotics), Analeptics/Nootropics (Stimulants), etc. Piperidine is a strong organic base and reacts violently with oxidizers.

참조 문헌

Rubiralta, M.; Giralt, E.; Diez, A. Piperidine: structure, preparation, reactivity, and synthetic applications of piperidine and its derivatives; Elsevier Science: Burlington, 2013; 460 p.

Srivastava, K.; Davis, M. A comparative examination of two Fmoc removal reagents for process improvement to produce peptide drugs. Adv. Exp. Med. Biol. 2009, 611, 585-91.

Base catalyst in the Doebner modification of the Knoevenagel condensation; see Malonic acid, A11526.

Widely used for cleavage of Fmoc protecting groups: J. Org. Chem., 52, 1197 (1987); Tetrahedron Lett., 34, 6135 (1993). See Appendix 6.

For preparation of the piperidine enamine of cyclooctanecarboxaldehyde, and its subsequent use in the synthesis of spirohexadienones, see: Org. Synth. Coll., 7, 473 (1990).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H225-H311-H331-H314

Highly flammable liquid and vapour. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage.

주의 설명서: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,7468
바일슈타인
102438
위험 등급
8
포장 그룹
I
통합 관세 코드
2933.32
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
TM3500000

권장

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    Trifluoroacetic acid, HPLC Grade, 99.5+%

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