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107-91-5 - Cyanoacetamide, 99% - Malonamide nitrile - A12482 - Alfa Aesar

A12482 Cyanoacetamide, 99%

CAS 번호
107-91-5
동의어
Malonamide nitrile

사이즈 가격 ($) 수량 재고 여부
100g 21.60
500g 72.60
2500g 286.00
장바구니에 추가 대량 견적에 추가 항목 보기

Cyanoacetamide, 99%

MDL
MFCD00008024
EINECS
203-531-8

화학적 특성

화학식
NCCH2CONH2
화학 식량
84.08
융점
118-122°
인화점
215°(419°F)
용해도
Soluble in water.

용도

Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum. Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.

참고

Store under cool dry place. Ensure good ventilation. Incompatible with oxidizing agents.

참조 문헌

Fadda AA, et al..; Turk. J. Cyanoacetamide derivatives as synthons in heterocyclic synthesis. J. Chem. 2008, 32 (3),259-286.

Honda S, et al. Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes. Anal. Chem. 1980, 52 (7), 1079-1082.

Review of utility in heterocyclic synthesis: Heterocycles, 24, 2023 (1986). Reaction with various enones and enals in the presence of KO-t-Bu and oxygen in DMSO provides a one-step route to functionalized 3-cyano-2-pyridones: Tetrahedron Lett., 36, 3307 (1995):

In the absence of oxygen, only Michael addition occurs.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,2688
바일슈타인
878221
통합 관세 코드
2926.90
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
AB5950000

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