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2226-96-2 - 4-Hydroxy-TEMPO, free radical, 98+% - 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical - A12497 - Alfa Aesar

A12497 4-Hydroxy-TEMPO, free radical, 98+%

CAS 번호
2226-96-2
동의어
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical

사이즈 가격 ($) 수량 재고 여부
1g 25.10
5g 67.00
25g 261.00
장바구니에 추가 대량 견적에 추가 항목 보기

4-Hydroxy-TEMPO, free radical, 98+%

MDL
MFCD00006478
EINECS
218-760-9

화학적 특성

화학식
C9H18NO2
화학 식량
172.25
융점
69-72°
인화점
146°(295°F)
용해도
Soluble in water, ethanol, methanol and dimethyl sulfoxide.

용도

Superoxide scavenger with neuroprotective, anti-inflammatory and analgesic effects4-Hydroxy-TEMPO free radical is used as a catalyst and a chemical oxidant by virtue of being a stable radical. It is used for detoxifying reactive oxygen species in medicinal chemistry. It is involved in the catalysis of disproportionation of superoxide and facilitates hydrogen peroxide metabolism. It is used to prepare tris(2,2,6,6-tetramethyl-1-oxyl-4-piperidyloxy)trimellitate by reacting with benzene-1,2,4-tricarbonyl trichloride. Further, it is used as a free radical scavenger and exhibits neuroprotective, anti-inflammatory and analgesic effects. In addition to this, it has good inhibition effect to acrylic acid esters, methyl acrylate, acrylic acid, acrylonitrile, styrene and butadiene.

참고

Store in a cool place. Incompatible with strong oxidizing agents.

참조 문헌

Reviews: Synthesis and reactions of stable nitroxyl radicals: Synthesis, 190, 401 (1971); Advances in the chemistry of nitroxide spin labels: Chem. Rev., 78, 37 (1978); Recent advances in the chemistry of nitroxides and their applications in spin labelling: J. Sci. Ind. Res., 54, 623 (1995). For a brief feature on derived oxoammonium salts, see: Synlett, 1757 (2003).

Compare also 4-Acetamido-TEMPO, B23456 and TEMPO, A12733.

Recommended as a stabilizer (antioxidant) for the protection of unsaturated fatty acids and their derivatives: J. Am. Chem. Soc., 101, 6748 (1979).

żamoj?, K.; Wiczk, W.; Zaborowski, B.; Jacewicz, D.; Chmurzyński, L. Analysis of Fluorescence Quenching of Coumarin Derivatives by 4-Hydroxy-TEMPO in Aqueous Solution. J. Fluoresc. 2014, 24 (3), 713-718.

żamoj?, K.; Zdrowowicz, M.; Wiczk, W.; Jacewicz, D.; Chmurzyński, L. Dihydroxycoumarins as highly selective fluorescent probes for the fast detection of 4-hydroxy-TEMPO in aqueous solution. RSC Adv. 2015, 5 (78), 63807-63812.

Sunkaria, A.; Sharma, D. R.; Wani, W. Y.; Gill, K. D. Attenuation of Dichlorvos-Induced Microglial Activation and Neuronal Apoptosis by 4-Hydroxy TEMPO. Mol. Neurobiol. 2014, 49 (1), 163-175.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

주의 설명서: P280-P305+P351+P338-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor

기타 참조

바일슈타인
1422990
통합 관세 코드
2933.39
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
TN8991000

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