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616-47-7 - 1-Methylimidazole, 99% - A12575 - Alfa Aesar

A12575 1-Methylimidazole, 99%

CAS 번호
616-47-7
동의어

사이즈 가격 ($) 수량 재고 여부
100g 27.60
500g 105.00
2kg 269.00
장바구니에 추가 대량 견적에 추가 항목 보기

1-Methylimidazole, 99%

MDL
MFCD00005292
EINECS
210-484-7

화학적 특성

화학식
C4H6N2
화학 식량
82.11
융점
-6°
비등점
195-197°
인화점
92°(197°F)
밀도
1.031
굴절률
1.4970
감도
Hygroscopic
용해도
Miscible with water.

용도

1-Methylimidazole is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate. It is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.

참고

Incompatible with carbon dioxide and strong oxidizing agents.

참조 문헌

Useful base for peptide coupling, etc. See, e.g.: J. Chem. Soc., Chem. Commun., 2223 (1995). For peptide reagents, see Appendix 6.

Undergoes lithiation at the 2-position. Reaction of the Li derivative with ketones followed by dehydration with acetic anhydride is a good route to 2-alkylideneimidazoles: Synthesis, 78 (1990). Likewise, reaction with benzonitrile gives the 2-benzoyl derivative, the carbonyl group of which undergoes Wittig methylenation: Synth. Commun., 20, 321 (1990).

Reacts with acid chlorides, including chloroformates, to give N-acylimidazolium salts, which are useful reagents for the acylation of, for example, amino acids: Bull. Soc. Chim. Fr., 1021 (1973).

Zhang, Y.; Yin, S. C.; Lu, J. M. N-Heterocyclic carbene-palladium(II)-1-methylimidazole complex catalyzed allyl-aryl coupling of allylic alcohols with arylboronic acids in neat water. Tetrahedron 2015, 71 (4), 544-549.

Guan, J. T.; Song, X. M.; Zhang, Z. Y.; Wei, B. M.; Dai, Z. Q. Catalytic activity of 1-methylimidazole-based phosphine ligands in the palladium-catalyzed Suzuki coupling reaction. Appl. Organomet. Chem. 2015, 29 (2), 87-89.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227-H302-H312-H314

Combustible liquid. Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage.

주의 설명서: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
105197
위험 등급
8
포장 그룹
III
통합 관세 코드
2933.29
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
NI7000000

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