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85-41-6 - Phthalimide, 99% - Benzene-1,2-dicarboxylic acid imide - Isoindole-1,3-dione - A12584 - Alfa Aesar

A12584 Phthalimide, 99%

CAS 번호
85-41-6
동의어
Benzene-1,2-dicarboxylic acid imide
Isoindole-1,3-dione

사이즈 가격 ($) 수량 재고 여부
500g 29.30
2500g 72.10
10000g 228.00
장바구니에 추가 대량 견적에 추가 항목 보기

Phthalimide, 99%

MDL
MFCD00005881
EINECS
201-603-3

화학적 특성

화학식
C8H5NO2
화학 식량
147.14
융점
232-236°
비등점
366°
인화점
165°(329°F)
밀도
1.21
용해도
Slightly soluble in water. Soluble in aqueous alkali hydroxides

용도

Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. . It is used as a precursor to other organic compounds as a masked source of ammonia.

참고

Store at room temperature. Ensure good ventilation.

참조 문헌

John C. Sheehan.; William A. Bolhofer. An Improved Procedure for the Condensation of Potassium Phthalimide with Organic Halides. J. Am. Chem. Soc. 1950, 72 (2), 2786-2788.

Lı?dia M Lima.; Paulo Castro.; Alexandre L Machado.; Carlos Alberto M Fraga.; Claire Lugnier.; Vera Lúcia Gonçalves de Moraes.; Eliezer J Barreiro. Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues. Bioorg. Med. Chem.. 2002, 10 (9),3067-3073.

For use in the Gabriel synthesis of primary amines, see: Potassium phthalimide, A11134. For an example of N-alkylation in the presence of K2CO3, see: Org. Synth. Coll., 2, 83 (1943). The N-alkylation by alkyl halides can be effected using KF, RbF or CsF as base; NaF and LiF are ineffective: J. Am. Chem. Soc., 99, 498 (1977).

The direct conversion of alcohols to N-alkylphthalimides and hence to amines can be effected in the presence of the Mitsunobu reagent: Org. Synth. Coll., 7, 501 (1990):

기타 참조

Merck
14,7373
바일슈타인
118522
통합 관세 코드
2925.19
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
TI3920000

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