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1885-14-9 - Phenyl chloroformate, 99% - Chloroformic acid phenyl ester - A12618 - Alfa Aesar

A12618 Phenyl chloroformate, 99%

CAS 번호
1885-14-9
동의어
Chloroformic acid phenyl ester

사이즈 가격 ($) 수량 재고 여부
100g 25.80
250g 60.80
500g 108.00
장바구니에 추가 대량 견적에 추가 항목 보기

Phenyl chloroformate, 99%

MDL
MFCD00000637
EINECS
217-547-8

화학적 특성

화학식
ClCO2C6H5
화학 식량
156.57
융점
-38°
비등점
188-189°
인화점
76°(169°F)
밀도
1.246
굴절률
1.5110
감도
Moisture Sensitive
용해도
Miscible with N,N-dimethylformamide.

용도

Phenyl chloroformate is used in the synthesis of poly(2-(phenoxycarbonyloxy)ethyl methacrylate) and phenyl-(4-vinylphenyl) carbonate. It acts as a precursor of phenyl mixed anhydrides which are used in peptide coupling reactions. It serves as a dehydrating reagent for the conversion of primary amides to nitriles and an intermediate in the synthesis of pharmaceuticals and carbamates.

참고

Store in cool place. Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with bases, alcohols and amines. Hydrolyses in water.

참조 문헌

Precursor of phenyl mixed anhydrides, which can be used, e.g. in peptide coupling reactions.

Also used in the cleavage of tertiary amines: J. Chem. Soc. (C), 2015 (1967); cf Ethyl­ chloroformate, L06311, and 1-Chloroethyl­ chloroformate, L14197. Review: Synthesis, 1 (1989).

Reagent for dehydration of primary amides to nitriles under mild conditions: Indian J. Chem., 40B, 722 (2001).

Wieting, J. M.; Fisher, T. J.; Schafer, A. G.; Visco, M. D.; Gallucci, J. C.; Mattson, A. E. Preparation and Catalytic Activity of BINOL-Derived Silanediols. Eur. J. Org. Chem. 2015, 2015 (3), 525-533.

Kevill, D. N.; Ryu, Z. H. Correlation of the rates of solvolysis of 2, 1-benzoxathiol-3-one-1, 1-dioxide (2-sulfobenzoic acid cyclic anhydride). J. Chem. Res. 2015, 39 (10), 561-566.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227-H302-H313-H330-H314-H318-H317

Combustible liquid. Harmful if swallowed. May be harmful in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction.

주의 설명서: P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
606778
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2915.90
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
FG3850000

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