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1118-02-1 - Trimethylsilyl isocyanate, 94% - A12633 - Alfa Aesar

A12633 Trimethylsilyl isocyanate, 94%

CAS 번호
1118-02-1
동의어

사이즈 가격 ($) 수량 재고 여부
10g 74.60
50g 296.00
250g 1250.00
장바구니에 추가 대량 견적에 추가 항목 보기

Trimethylsilyl isocyanate, 94%

MDL
MFCD00001993
EINECS
214-256-8

화학적 특성

화학식
C4H9NOSi
화학 식량
115.21
융점
-49°
비등점
90-92°
인화점
-2°(28°F)
밀도
0.859
굴절률
1.3960
감도
Moisture Sensitive
용해도
Miscible with ethers and o-dichlorobenzene.

용도

Trimethylsilyl isocyanate is used in the preparation of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones. It finds application in the carbamoylation of aromatic hydrocarbons and alcohols. It is also used in the preparation of primary amides from Grignard reagents. Further, it is used in the synthesis of cyclic imides. It is also utilized for the synthesis of trifluoroacetyl isocyanate and cyclic imides. In addition to this, it is employed in the conversion of isocyanates to carbodiimides using cyclopentadienyl Mn(CO)3 catalysis.

참고

Moisture sensitive. Incompatible with strong oxidizing agents, acids, strong bases, alcohols and amines.

참조 문헌

Convenient protected form of "HNCO". For reactions of isocyanates, see Appendix 3. Reaction with Grignard reagents leads to primary carboxamides: Tetrahedron Lett., 981 (1975).

Eriksson, J.; Kooij, R. V.; Schuit, R. C.; Froklage, F. E.; Reijneveld, J. C.; Hendrikse, N. H.; Windhorst, A. D. Synthesis of [3-N-11C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [11C]methyl iodide. J. Labelled Comp. Radiopharm. 2015, 58 (3), 122-126.

Iwata, Y.; Ando, K.; Taniguchi, K.; Koba, N.; Sugiura, A.; Sudo, M. Identification of a highly potent and selective CB2 agonist, RQ-00202730, for the treatment of irritable bowel syndrome. Bioorg. Med. Chem. Lett. 2015, 25 (2), 236-240.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H225-H330-H315-H319-H334-H335

Highly flammable liquid and vapour. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.

주의 설명서: P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
1744962
위험 등급
3
포장 그룹
II
통합 관세 코드
2931.90
TSCA(독성물질규제법)"
Yes

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