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62-56-6 - Thiourea, 99% - Thiocarbamide - A12828 - Alfa Aesar

A12828 Thiourea, 99%

CAS 번호
62-56-6
동의어
Thiocarbamide

사이즈 가격 ($) 수량 재고 여부
100g 24.70
500g 36.10
2500g 114.00
10000g 355.00
장바구니에 추가 대량 견적에 추가 항목 보기

Thiourea, 99%

MDL
MFCD00008067
EINECS
200-543-5

화학적 특성

화학식
CH4N2S
화학 식량
76.12
융점
172-178°
밀도
1.405
용해도
Soluble in water.

용도

Reagent for organic synthesisUsed as a reagent for organic synthesis. Thiourea is a photographic fixative, and used in manufacture of resins. It acts as a catalyst for asymmetric reactions. It plays an essential role as a catalyst for highly enantio- and diastereoselective additions reaction of oxindoles to nitroolefins. It is also useful to improve the productivity of mung bean.

참고

Stable. Incompatible with strong acids. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Handle and store under inert gas.

참조 문헌

Reagent for the conversion of alkyl halides to thiols by base hydrolysis of the isothiouronium salts; see also N-Acetyl­thiourea, B21198. Cleavage of isothiouronium salts with base and alkylation of the resulting thiolate has been used as a convenient synthesis of unsymmetrical sulfides: Synth. Commun., 14, 209 (1984).

Epoxides are converted to episulfides: J. Org. Chem., 26, 3467 (1961). The 2,3-epoxy alcohols resulting from the Sharpless enantioselective epoxidation can be converted to the corresponding episulfides with retention at both centers, using Ti(O-i-Pr)4 as mediator: J. Org. Chem., 53, 4114 (1988).

Widely used in heterocyclic syntheses, e.g. of thiazoles and pyrimidines.

Has been used in a convenient synthesis of isothiocyanates from oximes via the nitrile oxide: Tetrahedron Lett., 34, 8283 (1993); see also Benzaldoxime, A12053:

Bui, T.; Syed, S.; Barbas, C. F. Thiourea-Catalyzed Highly Enantio- and Diastereoselective Additions of Oxindoles to Nitroolefins: Application to the Formal Synthesis of (+) -Physostigmine. J. Am. Chem. Soc. 2009, 131 (25), 8758-8759.

Takemoto, Y. Development of Chiral Thiourea Catalysts and Its Application to Asymmetric Catalytic Reactions. Chem. Pharm. Bull. 2010, 58 (5), 593-601.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H351-H361

Harmful if swallowed. Suspected of causing cancer. Suspected of damaging fertility or the unborn child.

주의 설명서: P201-P280-P301+P312a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,9367
바일슈타인
605327
위험 등급
9
포장 그룹
III
통합 관세 코드
2930.90
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
YU2800000

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