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3958-60-9 - 2-Nitrobenzyl bromide, 98+% - alpha-Bromo-2-nitrotoluene - A13127 - Alfa Aesar

A13127 2-Nitrobenzyl bromide, 98+%

CAS 번호
3958-60-9
동의어
alpha-Bromo-2-nitrotoluene

사이즈 가격 ($) 수량 재고 여부
5g 46.60
25g 161.00
100g 567.00
장바구니에 추가 대량 견적에 추가 항목 보기

2-Nitrobenzyl bromide, 98+%

MDL
MFCD00007184
EINECS
223-558-9

화학적 특성

화학식
C7H6BrNO2
화학 식량
216.04
융점
45-48°
인화점
>110°(230°F)
용해도
Insoluble in water.

용도

2-Nitrobenzyl bromide is used in the preparation of S-2-nitrobenzyl-cysteine by reaction with L-cysteine. It is also used for the introduction of the 2-nitrobenzyl protecting group in organic synthesis. It plays an important role in the production of expectorant agent. Further, it is employed for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. In addition to this, it is used in the preparation of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.

참고

Moisture sensitive. Incompatible with alcohols, bases, amines and oxidizing agents.

참조 문헌

Photosensitive protecting reagent for alcohols, acids, phenols etc: J. Am. Chem. Soc., 91, 5694 (1969); J. Org. Chem., 37, 2281, 2285 (1972); Compare 4,5-Dimethoxy-2-nitrobenzyl­ alcohol, L00719. Has also been recommended for the protection of the imidazole function in histidine containing peptides: J. Am. Chem. Soc., 97, 440 (1975). See Appendix 6. It has been investigated as a photocleavable protecting group for various N-heterocycles: Tetrahedron Lett., 39, 359 (1998). For reviews of photoremovable groups in organic synthesis, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987).

Lee, S. J.; Fowler, J. S.; Alexoff, D.; Schueller, M.; Kim, D.; Nauth, A.; Weber, C.; Kim, S. W.; Hooker, J. M.; Ma, L.; Qu, W. An efficient and practical synthesis of [2-11C]indole via superfast nucleophilic [11C]cyanation and RANEY® Nickel catalyzed reductive cyclization. Org. Biomol. Chem. 2015, 13 (46), 11235-11243.

Bathula, C.; Dangi, P.; Hati, S.; Agarwal, R.; Munshi, P.; Singh, A.; Singh, S.; Sen, S. Diverse synthesis of natural product inspired fused and spiro-heterocyclic scaffolds via ring distortion and ring construction strategies. New J. Chem. 2015, 39 (12), 9281-9292.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H314-H318-H317

Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction.

주의 설명서: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
638991
위험 등급
8
포장 그룹
II
통합 관세 코드
2904.99
TSCA(독성물질규제법)"
No

권장

  • A10337

    4-Methylumbelliferone, 97%
  • A14610

    Tin(II) chloride dihydrate, 98%
  • A15496

    2-Nitrobenzyl alcohol, 97%
  • L16334

    Carbon, activated, Norit ROW 0.8mm pellets, steam activated
  • 14244

    Sodium nitrite, ACS, 97% min

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