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109-04-6 - 2-Bromopyridine, 99% - A13241 - Alfa Aesar

A13241 2-Bromopyridine, 99%

CAS 번호
109-04-6
동의어

사이즈 가격 ($) 수량 재고 여부
25g 32.10
100g 79.60
250g 160.00
500g 287.00
장바구니에 추가 대량 견적에 추가 항목 보기

2-Bromopyridine, 99%

MDL
MFCD00006219
EINECS
203-641-6

화학적 특성

화학식
C5H4BrN
화학 식량
158.00
비등점
192-194°
인화점
97°(207°F)
밀도
1.625
굴절률
1.5720
용해도
Slightly miscible with water.

용도

2-Bromopyridine is used in the preparation of a variety of biologically active compounds like antimalarial agents. It is also used to prepare beta-adrenoceptor agonist.

참고

Keep away from heat, sparks, and flame. Hygroscopic. Incompatible with strong oxidizing agents, strong acids and acid chlorides.

참조 문헌

Bromopyridines can be converted to the Grignards by Mg exchange with i-PrMgCl: Tetrahdron Lett., 40, 4339 (1999).

Reaction with n-BuLi gives 2-lithio-pyridine. Subsequent reaction at low temperatures with PCl3 gives, as the major product, 2,2'-bipyridine, along with a low yield of the expected tris(2-pyridyl)phosphine. POCl3 or SOCl2 also promote the symmetrical coupling reaction: Heteroatom. Chem., 5, 409 (1994). In contrast, reaction with LDA in THF at -78o results in lithiation at the 3-position, giving access to 3-substituted 2-bromopyridines: Synthesis, 235, 237 (1982). See also: Org. Lett., 3, 835 (2001).

Kathiravan, S.; Ghosh, S.; Hogarth, G.; Nicholls, I. A. Copper catalysed amidation of aryl halides through chelation assistance. Chem. Commun. 2015, 51 (23), 4834-4837.

Liu, C.; Li, X.; Liu, C.; Wang, X.; Qiu, J. Palladium-catalyzed ligand-free and efficient Suzuki-Miyaura reaction of heteroaryl halides with MIDA boronates in water. RSC Adv. 2015, 5 (67), 54312-54315.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H301-H310-H315-H319-H335

Toxic if swallowed. Fatal in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P280h-P305+P351+P338-P309-P310a

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor

기타 참조

바일슈타인
105789
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2933.39
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
US3850000

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