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51-21-8 - 5-Fluorouracil, 99% - 5-Fluoro-2,4(1H,3H)-pyrimidinedione - 5-FU - A13456 - Alfa Aesar

A13456 5-Fluorouracil, 99%

CAS 번호
51-21-8
동의어
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-FU

사이즈 가격 ($) 수량 재고 여부
5g 69.10
25g 280.00
100g 944.00
장바구니에 추가 대량 견적에 추가 항목 보기

5-Fluorouracil, 99%

MDL
MFCD00006018
EINECS
200-085-6

화학적 특성

화학식
C4H3FN2O2
화학 식량
130.08
융점
ca 282° dec.
감도
Light Sensitive
용해도
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

용도

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

참고

Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

참조 문헌

Antineoplastic agent. Not for drug use.

Cosco, D.; Paolino, D.; Maiuolo, J.; Di Marzio, L.; Carafa, M.; Ventura, C. A.; Fresta, M. Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. Int. J. Pharm. 2015, 489 (1-2), 1-10.

Wu, X.; He, C.; Wu, Y.; Chen, X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H341-H360-H373

Harmful if swallowed. Suspected of causing genetic defects. May damage fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure.

주의 설명서: P260-P201-P280-P301+P312a-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,4181
바일슈타인
127172
위험 등급
6.1
포장 그룹
III
통합 관세 코드
2933.59
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
YR0350000

권장

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