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366-77-8 - 3-(4-Fluorobenzoyl)propionic acid, 97% - A13755 - Alfa Aesar

A13755 3-(4-Fluorobenzoyl)propionic acid, 97%

CAS 번호
366-77-8
동의어

사이즈 가격 ($) 수량 재고 여부
5g 22.70
25g 90.20
장바구니에 추가 대량 견적에 추가 항목 보기

3-(4-Fluorobenzoyl)propionic acid, 97%

MDL
MFCD00002793
EINECS
206-679-1

화학적 특성

화학식
C10H9FO3
화학 식량
196.18
융점
99-103°
용해도
Insoluble in water.

용도

7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

참조 문헌

Lodewyk J. Mienie,; Jacobus J. Bergh,; Jeffrey R. Bloomquist,; Neal Castagnoli Jr.,; Stefanus J. Steyn,; Cornelis J. Van der Schyf. p-Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol. Life Sciences. 1999, 65 (5), 535-542.

Hyeon Soo Kim,; Minseok Song,; Sanatombi Yumkham,; Jang Hyun Choi,; Taehoon Lee,; Joseph Kwon,; Sung Jae Lee. Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid. Journal of Neurochemistry. 2006, 99(2), 458-469.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

기타 참조

바일슈타인
958145
통합 관세 코드
2918.30
TSCA(독성물질규제법)"
No

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