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77-76-9 - 2,2-Dimethoxypropane, 98% - Acetone dimethyl acetal - A13810 - Alfa Aesar

A13810 2,2-Dimethoxypropane, 98%

CAS 번호
77-76-9
동의어
Acetone dimethyl acetal

사이즈 가격 ($) 수량 재고 여부
100ml 18.80
500ml 35.50
2500ml 115.00
장바구니에 추가 대량 견적에 추가 항목 보기

2,2-Dimethoxypropane, 98%

MDL
MFCD00008479
EINECS
201-056-0

화학적 특성

화학식
(CH3O)2C(CH3)2
화학 식량
104.15
융점
-47°
비등점
79-81°
인화점
-11°(12°F)
밀도
0.848
굴절률
1.3780
용해도
Soluble in benzene, carbon tetrachloride, ethyl ether and n-butane, methanol. Moderately soluble in water.

용도

2,2-Dimethoxypropane acts as a dehydrating agent. It also serves as an intermediate in the synthesis of vitamin E, vitamin A and various carotenoids such as astaxanthin. It is used as a reagent for the preparation of 1,2-diols, acetonides, isopropylidene derivatives of sugars, nucleosides, methyl esters of amino acids and enol ethers.

참고

Incompatible with oxidizing agents and acids.

참조 문헌

Methoxylating agent for preparation of acetals by acid-catalyzed exchange: J. Org. Chem., 25, 521 (1960). Also used as a water-scavenger in the preparation of acetals from higher-boiling alcohols and ketones: Org. Synth. Coll., 5, 292 (1973).

Widely used for the isopropylidenation of diols; see, e.g.: Org. Synth. Coll., 9, 450, 717 (1998). Isopropylidenation of acid-sensitive carbohydrates in the presence of 2,3-Dichloro-5,6-dicyanobenzoquinone, A11879: Acta Chem. Scand., 47, 843 (1993); preparation of acyclic mixed acetals of carbohydrates: Acta Chem. Scand., 48, 80 (1994). For use in the cyclization of N-Boc serine methyl ester to the oxazolidine, see: Org. Synth. Coll., 9, 300 (1998).

Methyl ester hydrochlorides of amino acids can be conveniently prepared with excess reagent in combination with conc. HCl. Water is removed in situ, thus displacing the equilibrium in favor of the ester: J. Org. Chem., 28, 3898 (1963). Methyl esters of non-aromatic acids can also be prepared with the reagent in MeOH with a catalytic amount of HCl or TMS chloride: Tetrahedron Lett., 38, 2685 (1997).

/n

Urosa, A.; Marcos, I. S.; Díez, D.; Padrón, J. M.; Pilar Basabe, P. Synthesis of Luffarin L and 16-epi-Luffarin L Using a Temporary Silicon-Tethered Ring-Closing Metathesis Reaction. J. Org. Chem. 2015, 80 (12), 6447-6455.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H225-H319

Highly flammable liquid and vapour. Causes serious eye irritation.

주의 설명서: P210-P305+P351+P338

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

기타 참조

바일슈타인
635678
위험 등급
3
포장 그룹
II
통합 관세 코드
2911.00
TSCA(독성물질규제법)"
Yes

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