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An independent synthesis of 4-chloro-2-iodoanisole has shown that this is chlorinating agents, brominating agents and iodinating agents. 4-Chloro-2-iodoanisole (2) was demethylated and subsequently alkylated with 4-chloro-2-fluorobenzyl bromide, an aryl Grignard reagent was formed with it.
Herbert Henry Hodgson,; Arnold Kershaw. CCCXCIV.Halogenation of anisole derivative. J. Chem. Soc., 1929, 2917-2923.
Matthew Whiting,; Kathy Harwood,; Frank Hossner,; Peter G. Turner,; Mark C. Wilkinson. Selection and Development of the Manufacturing Route for EP1 Antagonist GSK269984B . Org. Process Res. Dev. 2010, 14 (14), 820-831.