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1068-90-2 - Diethyl acetamidomalonate, 98+% - Acetamidomalonic acid diethyl ester - A14048 - Alfa Aesar

A14048 Diethyl acetamidomalonate, 98+%

CAS 번호
1068-90-2
동의어
Acetamidomalonic acid diethyl ester

사이즈 가격 ($) 수량 재고 여부
25g 16.80
100g 32.30
500g 131.00
장바구니에 추가 대량 견적에 추가 항목 보기

Diethyl acetamidomalonate, 98+%

MDL
MFCD00009146
EINECS
213-952-9

화학적 특성

화학식
CH3CONHCH(CO2CH2CH3)2
화학 식량
217.22
융점
96-99°
비등점
185°/20mm
용해도
Soluble in chloroform and methanol. Slightly soluble in water.

용도

Diethyl 2-Acetamidomalonate, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin analogues as potential heat shock protein 90 inhibitors. It is also used as a important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals.

참고

Store in cool, dry place in tightly closed containers. Store away from oxidizing agent.

참조 문헌

Sambasivarao Kotha; Kuldeep Singh. N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis. Tetrahedron Letters. 2004, 45(52), 9607-9610.

Paul Angell; Peter G. Blazecka; Mark Lovdahl; and Ji Zhang. Indium(III)-Catalyzed Addition of Diethyl Acetamidomalonate to Terminal Alkynes:? An Efficient Approach to β-Branched α-Amino Acids. J. Org. Chem. 2007, 72(17), 6606-6609.

Intermediate for synthesis of racemic amino acids, by reaction with an electrophile, e.g alkyl halide, followed by hydrolysis and decarboxylation. The reactivity can be reversed by conversion to the dehydro-derivative, which then undergoes nucleophilic attack with alkyllithiums, Grignards, malonate anion, etc.: Angew. Chem. Int. Ed., 21, 203 (1982):

Substituents can also be introduced by Michael addition to a wide variety of acceptors: Synth. Commun., 18, 367 (1988).

For use in a novel pyrrole synthesis, see 1,4-Dichloro-2-butyne, A13300.

Compare also Diethyl­ formamidomalonate, L01189.

기타 참조

바일슈타인
783883
통합 관세 코드
2924.19
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
OO0360000

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화학물질

화학물질

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