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534-07-6 - 1,3-Dichloroacetone, 96% - 1,3-Dichloro-2-propanone - A14149 - Alfa Aesar

A14149 1,3-Dichloroacetone, 96%

CAS 번호
534-07-6
동의어
1,3-Dichloro-2-propanone

사이즈 가격 ($) 수량 재고 여부
25g 34.00
100g 128.00
500g 505.00
장바구니에 추가 대량 견적에 추가 항목 보기

1,3-Dichloroacetone, 96%

MDL
MFCD00000937
EINECS
208-585-6

화학적 특성

화학식
C3H4Cl2O
화학 식량
126.97
융점
40-44°
비등점
172-173°
인화점
95°(203°F)
밀도
1.383
굴절률
1.4400
용해도
Soluble in water, ethanol and diethyl ether.

용도

1,3-Dichloroacetone is used in the synthesis of citric acid. It is used as a solvent and as an intermediate in organic synthesis. Further, it serves as an acceptor substrate in the cross-aldol reaction with donor substrates such as acetone, cyclopentanone and cyclohexanone. It is also used in the preparation of an active pharmaceutical ingredient, famotidine.

참고

Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents, strong bases and reducing agents.

참조 문헌

Successive reaction with a Grignard reagent and Li metal leads to 1-substituted cyclopropanols, which rearrange on thermolysis to ethyl ketones: Synthesis, 647 (1983):

The cyclization can also be induced by ethyl radicals, generated from ethylmagnesium bromide and FeCl3. This method is applicable only to 1-arylcyclopropanols: J. Org. Chem., 29, 2813 (1964); 43, 3602 (1978); Org. Synth. Coll., 5, 1058 (1973).

Formation of the acetal followed by treatment with NaNH2 provides a route to cyclopropenones: Tetrahedron, 48, 2045 (1992).

Serrano, M.; Silva, M.; Gallego, M. Determination of 14 haloketones in treated water using solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. A 2015, 1407, 208-215.

Deng, J.; Chen, K.; Yao, Z.; Lin, J.; Wei, D. Efficient synthesis of optically active halogenated aryl alcohols at high substrate load using a recombinant carbonyl reductase from Gluconobacter oxydans. J. Mol. Catal. B: Enzym. 2015, 118, 1-7.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H300-H310-H330-H314-H318-H341

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing genetic defects.

주의 설명서: P273-P280-P305+P351+P338-P309-P310a-P501a

Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,3052
바일슈타인
605456
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2914.79
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
UC1430000

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