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10199-89-0 - 4-Chloro-7-nitrobenzofurazan, 99% - 4-Chloro-7-nitrobenzo-2,1,3-oxadiazole - NBD chloride - A14165 - Alfa Aesar

A14165 4-Chloro-7-nitrobenzofurazan, 99%

CAS 번호
10199-89-0
동의어
4-Chloro-7-nitrobenzo-2,1,3-oxadiazole
NBD chloride

사이즈 가격 ($) 수량 재고 여부
5g 47.70
25g 194.00
장바구니에 추가 대량 견적에 추가 항목 보기

4-Chloro-7-nitrobenzofurazan, 99%

MDL
MFCD00005808
EINECS
233-496-4

화학적 특성

화학식
C6H2ClN3O3
화학 식량
199.56
융점
96-100°
용해도
Soluble in methanol, dimethylsulfoxide, dimethylformamide and chloroform.

용도

4-Chloro-7-nitrobenzofurazan is used as a derivatizing reagent for chromatography analysis of amino acids and low molecular weight amines. It is utilized in the preparation of fluorescent phospholipid-derivative, hydroxynaphthofurazan and 4-chloro-7-nitrobenzofurazan- didecanoylphosphatidylethanolamine. It serves as a fluorescent reagent to label free sulfhydryls and N-terminals within proteins and trapping agent for cysteine sulfenic acid. It is a sensitive chromogenic and fluorogenic reagent. It reacts with trans-1-methoxy-3-(trimethylsilyloxy)-1,3-butadiene (Danishefsky's diene) to prepare regioselectively the silyl enol ether. Further, it is used to label peptides, proteins and other biomolecules. In addition it is used in the synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine, functionalized hydroxynaphthofurazan and 7-nitrobenzofurazan (NBD)-labeled maleimide.

참고

Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

참조 문헌

Fluorogenic reagent for amines and thiols: Anal. Biochem., 53, 290 (1973).

Reagent for pre-column derivatization of amines: Anal. Chim. Acta, 130, 377 (1981), 170, 81 (1985); and of imino acids: Anal. Biochem., 138, 390 (1984), allowing detection after HPLC.

Pan, J.; Zhang, Y.; Xu, J.; Liu, J.; Zeng, L.; Bao, G. M. A smart fluorescent probe for simultaneous detection of GSH and Cys in human plasma and cells. RSC Adv. 2015, 5 (118), 97781-97787.

Zhang, Y.; Chen, H.; Chen, D.; Wu, D.; Chen, X.; Liu, S. H.; Yin, J. A fluorescent turn-on H2S-responsive probe: design, synthesis and application. Org. Biomol. Chem. 2015, 13 (38), 9760-9766.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
614212
통합 관세 코드
2934.99
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
DF8002400

권장

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화학물질

화학물질

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