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4009-98-7 - (Methoxymethyl)triphenylphosphonium chloride, 98+% - A14380 - Alfa Aesar

A14380 (Methoxymethyl)triphenylphosphonium chloride, 98+%

CAS 번호
4009-98-7
동의어

사이즈 가격 ($) 수량 재고 여부
25g 53.40
100g 124.00
500g 449.00
장바구니에 추가 대량 견적에 추가 항목 보기

(Methoxymethyl)triphenylphosphonium chloride, 98+%

MDL
MFCD00011800
EINECS
223-664-5

화학적 특성

화학식
CH3OCH2P(C6H5)3Cl
화학 식량
342.81
융점
ca 190° dec.
감도
Hygroscopic
용해도
Soluble in methanol and chloroform. It decomposes in water.

용도

(Methoxymethyl)triphenylphosphonium chloride is used as a phase transfer catalyst and in the synthesis of taxol-A fragment. It is widely used in the synthesis of pharmaceutical product cephalotaxine, which is used as an antiviral and antitumor agent.

참고

Hygroscopic . Incompatible with strong oxidizing agents.

참조 문헌

Wittig reaction (see Appendix 1) of the derived phosphorane with aldehydes and ketones gives enol ethers, readily hydrolyzed to homologous aldehydes. For an example (adamantanone to adamantanecarboxaldehyde), see: Chem. Ber., 95, 2514 (1962). For use of the reaction in the synthesis of hydroisoquinoline AMPA antagonists, see: J. Med. Chem., 39, 2219 (1996). Reaction with chiral 2,3-epoxyaldehydes provides an enantioselective synthesis of (E)-4-hydroxyalkenes: J. Chem. Soc., Chem. Commun., 232 (1993).

/n

Lee, K.; Poudel, Y. B.; Glinkerman, C. M.; Boger, D. L. Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs. Tetrahedron 2015, 71 (35), 5897-5905.

Yu, Q.; Ma, S. An Enantioselective Synthesis of (R)-5,6-Octadecadienoic Acid. Eur. J. Org. Chem. 2015, 2015 (7), 1596-1601.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
924215
통합 관세 코드
2931.39
TSCA(독성물질규제법)"
No

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