Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

1660-94-2 - Tetraethyl methylenediphosphonate, 98+% - Methylenediphosphonic acid tetraethyl ester - A14532 - Alfa Aesar

A14532 Tetraethyl methylenediphosphonate, 98+%

CAS 번호
1660-94-2
동의어
Methylenediphosphonic acid tetraethyl ester

사이즈 가격 ($) 수량 재고 여부
5g 63.10
25g 253.00
100g 857.00
장바구니에 추가 대량 견적에 추가 항목 보기

Tetraethyl methylenediphosphonate, 98+%

MDL
MFCD00039887
EINECS
216-764-5

화학적 특성

화학식
C9H22O6P2
화학 식량
288.22
비등점
151-153°/1.2mm
인화점
>110°(230°F)
밀도
1.162
굴절률
1.4400
용해도
Slightly miscible with water.

용도

Tetraethyl methylidenediphosphonate is used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters. It acts as an intermediate for the synthesis of bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity. It is also used as a reactant for synthesis of dual substrate-site inhibitors of 3-deoxy-D-arabino-heputosonate 7-phosphate synthase and alpha-amino acid derivatives containing gem-biophosphonates, Lycopene through Wittig-Horner reaction. It is also used as a precursor for the preparation of dendritic polyglycerol anions.

참고

Incompatible with strong oxidizing agents.

참조 문헌

Reacts with aromatic aldehydes to give styrylphosphonates in a two-phase system, no added phase-transfer catalyst being necessary: Synthesis, 396 (1976). For cleavage of the resulting vinyl phosphonates to ɑ-hydroxyaldehydes, see Osmium(VIII)­ oxide, 12103.

Pachl, P.; Simak, O.; Rezacova, P.; Fabry, M.; Budesínsky, M.; Rosenberg, I.; Brynda, J. Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor. Med. Chem. Commun. 2015, 6 (9), 1635-1638.

Faísca Phillips, A. M.; Barros, M. T. Enantioselective Organocatalytic Synthesis of α-Cyclopropylphosphonates through a Domino Michael Addition/Intramolecular Alkylation Reaction. Eur. J. Org. Chem. 2014, 2014 (1), 152-163.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319

Causes skin irritation. Causes serious eye irritation.

주의 설명서: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

기타 참조

바일슈타인
1813241
통합 관세 코드
2931.39
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
SZ9150000

권장

최근에 본 것

화학물질

화학물질

금속 및 재료

촉매

분석 기기 및 실험실 용품