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683-08-9 - Diethyl methylphosphonate, 97% - Diethyl methanephosphonate - Methylphosphonic acid diethyl ester - A14772 - Alfa Aesar

A14772 Diethyl methylphosphonate, 97%

CAS 번호
683-08-9
동의어
Diethyl methanephosphonate
Methylphosphonic acid diethyl ester

사이즈 가격 ($) 수량 재고 여부
10g 90.20
25g 187.00
50g 362.00
장바구니에 추가 대량 견적에 추가 항목 보기

Diethyl methylphosphonate, 97%

MDL
MFCD00009813
EINECS
211-667-4

화학적 특성

화학식
C5H13O3P
화학 식량
152.13
비등점
194°
인화점
75°(167°F)
밀도
1.040
굴절률
1.4140
용해도
Miscible with water.

용도

Diethyl methylphosphonate is used as a precursor for the synthesis of gem-difluroalkenyphosphonate via reaction with alpha-trifluromethylstyrene. It is also used in the synthesis of phosphonylated peptides, fluoroalkyl alpha- and beta-aminophosphonates, pyridone alkaloids with neuritogenic activity and lipophilic meropenem-derived prodrugs.

참고

Incompatible with strong oxidizing agents and strong bases.

참조 문헌

For synthetic applications of the lithio-derivatives of esters of methanephosphonic acid, see Dimethyl­ methyl­phosphonate, A14268.

Dialkylation has been used in the synthesis of cyclobutanephosphonates which are intermediates in the synthesis of 3-phosphonocyclobutyl amino acids: J. Chem. Soc., Perkin 1, 493 (1997).

Reaction of the lithio-derivative with dialkyl cyanamides gives, instead of the expected 2-phosphorylacetamide, a rearranged N-phosphorylated amidine: Chem. Commun., 609 (1998):

Mattea, F.; Peters, C. J.; Kroon, M. C. Experimental Determination of the Solubilities of CO2 and CH4 in Diethyl Methylphosphonate. J. Chem. Eng. Data 2011, 56 (6), 2960-2963.

JeongaJang, Y.; Murale, D. P.; Churchill, D. G. Novel reversible and selective nerve agent simulant detection in conjunction with superoxide “turn-on” probing. Analyst 2014, 139 (7), 1614-1617.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P210u-P261-P280a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
1753416
통합 관세 코드
2931.39
TSCA(독성물질규제법)"
No
RTECS(화학물질 독성 등록)
SZ9085000

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