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5329-33-9 - O-Methylisourea hydrochloride, 98% - A14773 - Alfa Aesar

A14773 O-Methylisourea hydrochloride, 98%

CAS 번호
5329-33-9
동의어

사이즈 가격 ($) 수량 재고 여부
10g 67.90
50g 299.00
250g 1263.00
장바구니에 추가 대량 견적에 추가 항목 보기

O-Methylisourea hydrochloride, 98%

MDL
MFCD00035043

화학적 특성

화학식
C2H6N2O•HCl
화학 식량
110.54
융점
ca 116° dec.
용해도
Soluble in organic solvents, water, methanol and ethanol.

용도

O-methylisourea hydrochloride is used to prepare 1-chloro-2-methyl-isourea. It is also used as an organic intermediate.

참고

Incompatible with strong oxidizing agents.

참조 문헌

Useful intermediate, more nucleophilic than urea itself, and avoiding toxicity of thiourea, in the synthesis of pyrimidines, by condensation with ß-diketones: Chem. Ber., 109, 3255 (1976); and of uracils, by condensation with ß-keto esters: Tetrahedron, 40, 3313 (1984); J. Heterocycl. Chem., 26, 883 (1989).

Reagent for guanylation of primary and secondary amines: Chem.-Ztg., 98, 617 (1974).

Reagent for selective methylation of SH groups at pH 8.5: Biochemistry, 9, 3343 (1970); 11, 110 (1972).

For a review of the synthetic applications of isoureas, see: Org. Prep. Proced. Int., 12, 309 (1980).

Paul, S.; Pattanayak, S.; Sinha, S. Synthesis and cell transfection properties of cationic uracil-morpholino tetramer. Tetrahedron Lett. 2014, 55 (5), 1072-1076.

Le?tinois, U.; Schu?tz, J.; Ha?rter, R.; Stoll, R.; Huffschmidt, F.; Bonrath, W.; Karge, R. Lewis acid-catalyzed synthesis of 4-aminopyrimidines: a scalable industrial process. Org. Process Res. Dev. 2013, 17 (3), 427-431.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
3909619
통합 관세 코드
2924.19
TSCA(독성물질규제법)"
Yes

권장

  • B21675

    Trichloroacetyl chloride, 99%
  • H27499

    (S)-1-Cyclopropylethylamine, ChiPros®, 98%, ee 98+%

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