Vitamin B12 is used as a nutritional supplement and stabilizer in foods. It is also used as a medicine and animal feed supplement. It plays an important role in the synthesis of myelin. It is also used as an antipernicious anemia factor. Further, it is used to treat cyanide poisoning and hereditary deficiency of transcobalamin II.
For monographs, see: B 12 (2 vols), D. Dolphon, Ed., Wiley-Interscience, N.Y. (1982); B 12 and B 12 -Proteins, B. Kraeutler, T Golding, Eds., Wiley-VCH, Weinheim (1998).
For a review, see: Vitamins, W. Friedrich, Ed., de Gruyter, Berlin (1988), pp 837-928.
For review of biosynthesis, see: Angew. Chem. Int. Ed., 32, 1223 (1993).
Almeida, O. P.; Ford, A. H.; Flicker, L. Systematic review and meta-analysis of randomized placebo-controlled trials of folate and vitamin B12 for depression. Int. Psychogeriatr. 2015, 27 (05), 727-737.
Lam, J. R.; Schneider, J. L.; Zhao, W.; Corley, D. A. P. Proton Pump Inhibitor and Histamine 2 Receptor Antagonist Use and Vitamin B12 Deficiency. JAMA 2013, 310 (22), 2435-2442.