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431-35-6 - 1-Bromo-3,3,3-trifluoroacetone, 97% - 3-Bromo-1,1,1-trifluoroacetone - 1-Bromo-3,3,3-trifluoro-2-propanone - A14948 - Alfa Aesar

A14948 1-Bromo-3,3,3-trifluoroacetone, 97%

CAS 번호
431-35-6
동의어
3-Bromo-1,1,1-trifluoroacetone
1-Bromo-3,3,3-trifluoro-2-propanone

사이즈 가격 ($) 수량 재고 여부
5g 36.40
25g 159.00
100g 560.00
장바구니에 추가 대량 견적에 추가 항목 보기

1-Bromo-3,3,3-trifluoroacetone, 97%

MDL
MFCD00039237
EINECS
207-071-9

화학적 특성

화학식
BrCH2COCF3
화학 식량
190.95
융점
<-80°
비등점
85-87°
인화점
-2°(28°F)
밀도
1.822
굴절률
1.3760
용해도
Immiscible with water.

용도

1-Bromo-3,3,3-trifluoroacetone is used in the preparation of 3-nonylthio-1,1,1-trifluoropropan-2-one and perfluoroalkylated trans-allylic alcohols. It is involved in the synthesis of cyclic tetrapeptides. Further, it reacts with potassium enolate of ethyl 4,4,4-trifluoroacetoacetate to produce ethyl 2,4-bis(trifluoromethyl)-4-hydroxydihydro-3-furoate.

참고

Incompatible with strong oxidizing agents and bases.

참조 문헌

A novel reductive olefination reaction with aldehydes, mediated by Ti(O-i-Pr)4 and PPh3, provides a one-pot synthesis of trifluoromethylated trans-allylic alcohols: Chem. Commun., 2195 (1998):

The oxime is readily converted with base to the highly reactive species 1,1,1-trifluoro-2-nitroso-2-propene, which undergoes hetero-Diels-Alder reactions, e.g. with cyclopentadiene or indole to give fused oxazolines. The indole adduct rearomatizes to give 1-(3-indolyl)-3,3,3-trifluoroacetoxime: J. Org. Chem., 57, 339 (1992).

Hiraoka, Y.; Kawasaki-Takasuka, T.; Morizawa, Y.; Yamazaki, T. Synthetic utility of 2,3,3,3-tetrafluoroprop-1-ene (HFO-1234yf). J. Fluorine Chem. 2015, 179, 71-76.

Dalmal, T.; Appalanaidu, K.; Kosurkar, U. B.; Jagadeesh Babu, N.; Kumbhare, R. M. One-Pot Synthesis of 2-Imino-4-(trifluoromethyl)thiazolidin-4-ol Derivatives in a Three-Component Reaction: Application to Structurally Diverse Scaffolds of Biological Interest Through Subsequent Reactions. Eur. J. Org. Chem. 2014, 2014 (12), 2468-2479.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
1703387
위험 등급
3
포장 그룹
II
통합 관세 코드
2914.79
TSCA(독성물질규제법)"
No

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