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It is used as a chiral building-block in the synthesis of the (S)-isomer of -butyrolactone-4-carboxylic acid. L-Glutamic acid is widely used in fields of medicine, food processing, industry, etc.
Watkins.; Evans. Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 1981, 165, (21), 354-362.
Monaghan et al . The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu.Rev.Pharmacol.Toxicol. 1989, 365, (29), 382-385.
For use as a chiral building-block in the synthesis of the (S)-isomer of -butyrolactone-4-carboxylic acid, see: Org. Synth. Coll., 7, 99 (1990):
For the differential protection of the ɑ-carboxyl group of N-protected glutamic acid by reaction with formaldehyde to form the cyclic 5-oxazolidinone, see: Synthesis, 542 (1989).