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109-77-3 - Malononitrile, 99% - Dicyanomethane - Propanedinitrile - A15046 - Alfa Aesar

A15046 Malononitrile, 99%

CAS 번호
109-77-3
동의어
Dicyanomethane
Propanedinitrile

사이즈 가격 ($) 수량 재고 여부
100g 22.50
500g 80.50
2500g 337.00
장바구니에 추가 대량 견적에 추가 항목 보기

Malononitrile, 99%

MDL
MFCD00001883
EINECS
203-703-2

화학적 특성

화학식
C3H2N2
화학 식량
66.06
융점
30-34°
비등점
220-222°
인화점
112°(233°F)
밀도
1.049
굴절률
1.4150
용해도
Soluble in water, acetone, acetic acid, chloroform, ethanol, ether and benzene.

용도

Crosslinking agent for modification of proteins via amidationMalononitrile is used as a precursor in the preparation of anti-cancer drug, triamterene, adenine, methotrexate, thiamine, acrylic fibers and dyes. It is used in Knoevenagel condensation to prepare 2-chlorobenzalmalononitrile by reacting with 2-chlorobenzaldehyde. It acts as a leaching agent for gold. It is used as a raw material for the Gewald reaction of ketone or aldehyde to produce 2-aminothiophene using elemental sulfur and a base. Further, it plays an important role in the preparation of [1,6]-naphthyridines, gamma-ketoamides, 1,4-dihydropyridine, chromeno[2,3-b]pyridine and dihydro-1,4-dithiepine frameworks.

참고

Store in a cool place. Incompatible with strong oxidizing agents, strong reducing agents, strong acids and strong bases.

참조 문헌

The Na derivative can be arylated by reaction with aryl halides with a Pd catalyst: J. Chem. Soc., Chem. Commun., 932 (1984). In the presence of butadiene, an additional 4-carbon unit is introduced: J. Chem. Soc., Perkin 1, 647 (1990):

Ternary condensation with an aromatic aldehyde and a cycloalkanone in the presence of ammonium acetate can give a variety of products. With cyclohexanone, the 2-amino-4-aryl-5,6,7,8-tetrahydroquinoline-3-carbonitriles are the major products: J. Chem. Res. (Synop.), 146 (1995).

Reviews of the chemistry of malononitrile: Chem. Rev., 69, 591 (1969); Synthesis, 165, 241 (1978); 925 (1981); Synlett, 2247 (2004).

Caruana, L.; Mondatori, M.; Corti, V.; Morales, S.; Mazzanti, A.; Fochi, M.; Bernardi, L. Catalytic Asymmetric Addition of Meldrum’s Acid, Malononitrile, and 1,3-Dicarbonyls to ortho-Quinone Methides Generated In Situ Under Basic Conditions. Chem. Eur. J. 2015, 21 (16), 6037-6041.

Adili, A.; Tao, Z. L.; Chen, D. F.; Han, Z. Y. Quinine-catalyzed highly enantioselective cycloannulation of o-quinone methides with malononitrile. Org. Biomol. Chem. 2015, 13 (8), 2247-2250.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H301-H311-H331

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.

주의 설명서: P261-P280h-P301+P310a-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,5711
바일슈타인
773697
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2926.90
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
OO3150000

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