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305-01-1 - 6,7-Dihydroxycoumarin, 98+% - Cichorigenin - Esculetin - A15393 - Alfa Aesar

A15393 6,7-Dihydroxycoumarin, 98+%

CAS 번호
305-01-1
동의어
Cichorigenin
Esculetin

사이즈 가격 ($) 수량 재고 여부
1g 47.70
5g 170.00
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6,7-Dihydroxycoumarin, 98+%

MDL
MFCD00006874
EINECS
206-161-5

화학적 특성

화학식
C9H6O4
화학 식량
178.15
융점
ca 270° dec.
용해도
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

용도

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

참조 문헌

Neichi Tomohiro; Koshihara Yasuko; Murota Sei-Itsu. Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 753 (1), 130-132.

Chia-Yih Chu; Yu-Ying Tsai; Chau-Jong Wang; Wei-Long Lin; Tsui-Hwa Tseng. Induction of apoptosis by esculetin in human leukemia cells. European Journal of Pharmacology. 2001, 416 (1-2), 25-32.

Ultraviolet absorbent.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,3697
바일슈타인
152788
통합 관세 코드
2932.20
TSCA(독성물질규제법)"
No
RTECS(화학물질 독성 등록)
GN6382500

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