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1722-12-9 - 2-Chloropyrimidine, 98% - A15394 - Alfa Aesar

A15394 2-Chloropyrimidine, 98%

CAS 번호
1722-12-9
동의어

사이즈 가격 ($) 수량 재고 여부
10g 53.90
25g 91.20
100g 293.00
장바구니에 추가 대량 견적에 추가 항목 보기

2-Chloropyrimidine, 98%

MDL
MFCD00006060
EINECS
217-020-2

화학적 특성

화학식
C4H3ClN2
화학 식량
114.54
융점
64-67°
비등점
75-76°/10mm
인화점
98°(208°F)
감도
Moisture Sensitive
용해도
Slightly soluble in water. 33.3 mg soluble in 1 mL of alcohol.

용도

2-Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds. It was used in the synthesis of 4?-(1,1?-(5-(2-methoxyphenoxy)-[2,2?-bipyrimidine]-4,6-diyl)bis(1H-pyrazol-3,1-diyl)) dianiline fluorescent dye, biosensor for protein assay, 2-amino-4-heteroarylpyrimidines, cis- and trans-octahydropyrrolo[2,3]pyridine derivatives.

참고

Moisture sensitive. Store under inert gas. Store away from moisture, oxidizing agents. Store in refrigerator.

참조 문헌

Jeanne-Marie Bégouin and Corinne Gosmini. Cobalt-Catalyzed Cross-Coupling Between In Situ Prepared Arylzinc Halides and 2-Chloropyrimidine or 2-Chloropyrazine. J. Org. Chem. 2009, 74 (8), 3221-3224.

Y.Anantharama Sarma. Planar vibrations of 2-chloropyrimidine. Spectrochimica Acta Part A: Molecular Spectroscopy. 1974, 30 (9), 1801-1806.

Alkoxylation with 3-butyn-1-ol, followed by intramolecular Diels-Alder reaction, leads to a fused pyridine system, by a sequence analogous to that shown for 2-Chloropyrazine, A10108: Tetrahedron, 45, 803 (1989). For a similar sequence using the anion of an alkynylmalononitrile, see: Tetrahedron, 45, 5151 (1989). For synthesis of a benzofuropyridine by the cyclization of a 2-(alkynylphenoxy)pyrimidine, see: Tetrahedron, 45, 6511 (1989).

Organolithium reagents add to the 1,6-imine bond, giving, after aromatization with DDQ, 6-substituted 2-chloropyrimidines: J. Org. Chem., 53, 4137 (1988).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H319-H317-H335

Harmful if swallowed. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
107171
위험 등급
6.1
포장 그룹
III
통합 관세 코드
2933.59
TSCA(독성물질규제법)"
No

권장

  • A10108

    2-Chloropyrazine, 98%
  • A10419

    Pyridine N-oxide, 95%
  • A12900

    2-Cyanopyridine, 99%
  • A14866

    2-Chloropyridine, 99%
  • L14357

    Methacrylic anhydride, 94%, stab. with ca 0.2% 2,4-dimethyl-6-tert-butylphenol

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