2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.
Tim H.M Jonckers; Bert U.W Maes; Guy L.F Lemière; Roger Dommisse. Selective palladium-catalyzed aminations on dichloropyridines.Journal of Molecular Structure.2001, 57 7027-7034.
Elena Marzi; Anna Bigi and Manfred Schlosser. Strategies for the Selective Functionalization of Dichloropyridines at Various Sites. European Journal of Organic Chemistry.2001, 2001 1371-1376.
해저드 설명서 (EU): H302-H311-H315-H319-H335
Harmful if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
주의 설명서: P280h-P305+P351+P338-P309+P311-P302+P352a
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of water.