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771-61-9 - Pentafluorophenol, 99% - PFP - A15574 - Alfa Aesar

A15574 Pentafluorophenol, 99%

CAS 번호
771-61-9
동의어
PFP

사이즈 가격 ($) 수량 재고 여부
5g 28.50
25g 105.00
100g 354.00
장바구니에 추가 대량 견적에 추가 항목 보기

Pentafluorophenol, 99%

MDL
MFCD00002156
EINECS
212-235-8

화학적 특성

화학식
C6HF5O
화학 식량
184.06
융점
32-36°
비등점
143°
인화점
72°(161°F)
밀도
1.757
굴절률
1.4270
용해도
Soluble in water.

용도

Pentafluorophenol is used in the preparation of pentafluorophenyl esters for peptide synthesis and vulcanized polymers. It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl formate which acts as a formulating agent for amines and amino acids.

참고

Moisture sensitive. Incompatible with strong oxidizing agents, bases, acid chlorides and acid anhydrides.

참조 문헌

Widely used for peptide coupling (see Appendix 6) via the active PFP esters, generally prepared by carbodiimide coupling: Liebigs Ann. Chem., 1421 (1973); Tetrahedron Lett., 1785 (1974). With Fmoc-protected amino acids, the coupling takes place very rapidly, which reduces the amount of Fmoc-cleavage during the peptide bond formation: Synthesis, 325 (1983). Fmoc protected PFP esters have also been applied in solid phase peptide synthesis: Tetrahedron, 44, 843 (1988). PFP esters have been recommended for preparation of derivatives of heterocyclic acids, effective where DCC or DIC alone fail: Synth. Commun., 28, 753 (1998).

For preparation and use of the moderately stable PFP formate as a formylating agent for amines and amino acids, see: Synthesis, 510 (1987).

Pandith, A.; Kumar, A.; Kim, H. S. 9-N-Alkylaminomethylanthracene probes for selective fluorescence sensing of pentafluorophenol. RSC Adv. 2015, 5 (100), 81808-81816.

Alonso, J. M.; Fabre, B.; Trilling, A. K.; Scheres, L.; Franssen, M. C.; Zuilhof, H. Covalent Attachment of 1-Alkenes to Oxidized Platinum Surfaces. Langmuir. 2015, 31 (9), 2714-2721.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H312-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
1912584
통합 관세 코드
2908.19
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
SM6680000

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