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70-11-1 - 2-Bromoacetophenone, 98% - Phenacyl bromide - A15576 - Alfa Aesar

A15576 2-Bromoacetophenone, 98%

CAS 번호
70-11-1
동의어
Phenacyl bromide

사이즈 가격 ($) 수량 재고 여부
25g 28.20
100g 67.90
500g 231.00
장바구니에 추가 대량 견적에 추가 항목 보기

2-Bromoacetophenone, 98%

MDL
MFCD00000195
EINECS
200-724-9

화학적 특성

화학식
C8H7BrO
화학 식량
199.05
융점
48-51°
비등점
140°/11mm
인화점
>110°(230°F)
밀도
1.650
용해도
Insoluble in water.

용도

It is used in preparation of crystalline esters from acids. 2-Bromoacetophenone is a complete and irreversible inactivator of human liver aldehyde dehydrogenase isoenzymes E1 and E2.

참고

Store in a cool, dry conditions in a well sealed container. Incompatible with oxidizing agent, acids & bases.

참조 문헌

E Bielak; S Biliński. [Reactions of 1-(X-benzoyl)-4-R-thiosemicarbazide with chloroacetone and µ-bromoacetophenone. VI. 4-(o-tolyl)-thiosemicarbazide of o-nitro - and p-nitrobenzoic acid]. Annales UMCS Medicina. 1996,51 185-193.

Adolfo Lopez Torres; Eunice Yanez Barrientos; Katarzyna Wrobel; Kazimierz Wrobel. Selective derivatization of cytosine and methylcytosine moieties with 2-bromoacetophenone for submicrogram DNA methylation analysis by reversed phase HPLC with spectrofluorimetric detection. Analytical chemistry 2011, 83 (20), 7999-8005.

Reagent for carboxyl protection as phenacyl esters, stable to acid hydrolysis but readily cleaved by nucleophiles or by reduction. See Appendix 6. Protection can be effected in the presence of triethylamine: J. Chem. Soc. (C), 1191 (1966), or, better, KF in DMF: Tetrahedron Lett., 599 (1977). Phase-transfer conditions have also been reported: Synth. Commun., 26, 1747 (1996). Cleavage has been described using a variety of reagents, including Zn-AcOH: Tetrahedron Lett., 343 (1970), catalytic hydrogenolysis, treatment with PhS-, PhSeH, or NaHTe: Synth. Commun., 18, 116 (1988); TBAF: J. Org. Chem., 56, 5465 (1991); or photolysis: J. Org. Chem., 62, 6245 (1997).

Has also been used to block the imidazole ring in histidine residues during peptide synthesis, and is stable to TFA, TfOH and HBr-AcOH: J. Chem. Soc., Chem. Commun., 472 (1978); J. Chem. Soc., Perkin 1, 2261 (1979).

For formation of the Sn enolate using SnCl2, see: Synth. Commun., 23, 271 (1993). 1,4-Diketones may be synthesized from ɑ-bromoketones and Sn enolates: J. Chem. Soc., Perkin 1, 3205 (1990).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H331-H314-H318

Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P280-P305+P351+P338-P309-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor

기타 참조

Merck
14,1402
바일슈타인
606474
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2914.79
TSCA(독성물질규제법)"
Yes

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