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36239-09-5 - Ethyl malonyl chloride, 95% - Ethyl (chloroformyl)acetate - Malonic acid monoethyl ester chloride - A15616 - Alfa Aesar

A15616 Ethyl malonyl chloride, 95%

CAS 번호
36239-09-5
동의어
Ethyl (chloroformyl)acetate
Malonic acid monoethyl ester chloride

사이즈 가격 ($) 수량 재고 여부
5g 50.40
25g 175.00
100g 561.00
장바구니에 추가 대량 견적에 추가 항목 보기

Ethyl malonyl chloride, 95%

MDL
MFCD00000736
EINECS
252-934-5

화학적 특성

화학식
C5H7ClO3
화학 식량
150.56
비등점
83°/22mm
인화점
67°(152°F)
밀도
1.189
굴절률
1.4290
감도
Moisture Sensitive
용해도
Miscible with water.

용도

Ethyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

참고

Store in cool place. Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with alcohols. It reacts with water.

참조 문헌

Useful synthetic building block, e.g. in an oxazole synthesis: J. Med. Chem., 36, 3871 (1993):

Formation of amides has been used in the syntheses of 1,2,4-triazine-3,6-diones, and of a vicinal tricarbonyl amide derivative of L-phenylalanine: J. Org. Chem., 60, 5992 (1995); 61, 1872 (1996).

Yang, Z.; Li, S.; Zhang, Z.; Xu, J. Base-switched annuloselectivity in the reactions of ethyl malonyl chloride and imines. Org. Biomol. Chem. 2014, 12 (48), 9822-9830.

Hayat, F.; Kang, L.; Lee, C. Y.; Shin, D. Synthesis of arylnaphthalene lignan lactone using benzoin condensation, intramolecular thermal cyclization and Suzuki coupling. Tetrahedron 2015, 71 (19), 2945-2950.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227-H314-H318

Combustible liquid. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
636215
위험 등급
8
포장 그룹
II
통합 관세 코드
2917.19
TSCA(독성물질규제법)"
No

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