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35386-24-4 - 1-(2-Methoxyphenyl)piperazine, 98% - A15819 - Alfa Aesar

A15819 1-(2-Methoxyphenyl)piperazine, 98%

CAS 번호
35386-24-4
동의어

사이즈 가격 ($) 수량 재고 여부
5g 30.90
100g 312.00
장바구니에 추가 대량 견적에 추가 항목 보기

1-(2-Methoxyphenyl)piperazine, 98%

MDL
MFCD00005958
EINECS
252-537-7

화학적 특성

화학식
C11H16N2O
화학 식량
192.26
융점
35-39°
비등점
130-133°/0.1mm
인화점
>110°(230°F)
밀도
1.106
감도
Air Sensitive
용해도
Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water

용도

It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.

참고

Air sensitive. Store at room temperature. Keep away from oxidizing agents.

참조 문헌

Anneke Hackling.; Robin Ghosh.; Sylvie Perachon.; André Mann.; Hans-Dieter Höltje.; Camille G. Wermuth..; Jean-Charles Schwartz .;Wolfgang Sippl.;Pierre Sokoloff.; Holger Stark. N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands. J. Med. Chem. 2003, 46 (18),3883-3899 .

Jerzy L. Mokrosz.; Maria H. Paluchowska.; Ewa Chojnacka-Wojcik.; Malgorzata Filip.; Sijka Charakchieva-Mino.; Anna Deren-Wesolek.; Maria J. Mokrosz. Structure-Activity Relationship Studies of Central Nervous System Agents. 13.4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a New Putative 5-HT1A Receptor Antagonist, and Its Analogs. J. Med. Chem. 1994, 37 (17), 2754-2760 .

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H301-H314-H318

Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a

Do not breathe dusts or mists. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
167888
위험 등급
8
포장 그룹
III
통합 관세 코드
2933.59
TSCA(독성물질규제법)"
No

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