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It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.
Anneke Hackling.; Robin Ghosh.; Sylvie Perachon.; André Mann.; Hans-Dieter Höltje.; Camille G. Wermuth..; Jean-Charles Schwartz .;Wolfgang Sippl.;Pierre Sokoloff.; Holger Stark. N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands. J. Med. Chem. 2003, 46 (18),3883-3899 .
Jerzy L. Mokrosz.; Maria H. Paluchowska.; Ewa Chojnacka-Wojcik.; Malgorzata Filip.; Sijka Charakchieva-Mino.; Anna Deren-Wesolek.; Maria J. Mokrosz. Structure-Activity Relationship Studies of Central Nervous System Agents. 13.4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a New Putative 5-HT1A Receptor Antagonist, and Its Analogs. J. Med. Chem. 1994, 37 (17), 2754-2760 .
해저드 설명서 (EU): H301-H314-H318
Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
주의 설명서: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
Do not breathe dusts or mists. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.