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107-59-5 - tert-Butyl chloroacetate, 98% - Chloroacetic acid tert-butyl ester - A15833 - Alfa Aesar

A15833 tert-Butyl chloroacetate, 98%

CAS 번호
107-59-5
동의어
Chloroacetic acid tert-butyl ester

사이즈 가격 ($) 수량 재고 여부
25g 23.90
100g 65.20
500g 244.00
장바구니에 추가 대량 견적에 추가 항목 보기

tert-Butyl chloroacetate, 98%

MDL
MFCD00000930
EINECS
203-506-1

화학적 특성

화학식
C6H11ClO2
화학 식량
150.61
비등점
155°
인화점
46°(115°F)
밀도
1.053
굴절률
1.4230
용해도
Decomposes in water.

용도

tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Moisture sensitive. Incompatible with strong bases and strong oxidizing agents.

참조 문헌

Santosh Kumar Singh.; Narendra Manne.; Purna Chandra Ray.; Manojit Pal. Synthesis of imidazol-1-yl-acetic acid hydrochloride: a key intermediate for zoledronic acid. Beilstein Journal of Organic Chemistry. 2008, 4 42.

E Vedejs.; D W Piotrowski.; F C Tucci. Oxazolium-derived azomethine ylides. External oxazole activation and internal dipole trapping in the synthesis of an aziridinomitosene. Journal of Organic Chemistry. 2000, 65 (18), 5498-5505.

Darzens condensation (see Ethyl­ chloroacetate, A15554) with carbonyl compounds gives t-butyl glycidic esters, which readily undergo decarboxylative elimination to the homologous aldehydes. See, for example: Rec. Trav. Chim., 89, 18 (1970).

The reaction with imines has also been used in the preparation of aziridines by a nitrogen analogue of the Darzens reaction: J. Chem. Soc., Chem. Commun., 602 (1977).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H226-H302-H312-H331-H315-H319-H335

Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P273-P280h-P305+P351+P338-P309-P310a-P501a

Avoid release to the environment. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,1563
바일슈타인
1753006
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2915.40
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
AF8985500

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