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123-99-9 - Azelaic acid, tech. 80% - Nonanedioic acid - A17271 - Alfa Aesar

A17271 Azelaic acid, tech. 80%

CAS 번호
123-99-9
동의어
Nonanedioic acid

사이즈 가격 ($) 수량 재고 여부
500g 34.10
2500g 126.00
장바구니에 추가 대량 견적에 추가 항목 보기

Azelaic acid, tech. 80%

MDL
MFCD00004432
EINECS
204-669-1

화학적 특성

화학식
HOOC(CH2)7COOH
화학 식량
188.22
융점
ca 102°
비등점
286°/100mm
인화점
215°(419°F)
밀도
1.225
용해도
Soluble in water at 20°C 2.4 g/L. Soluble in ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.

용도

It is applied in organic synthesis, lacquers, polyester adhesives, and urethane elastomers. Azelaic acid directly inhibits kallikrein 5 (KLK5), down regulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and up regulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPAR? is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. It is a component of a number of hair and skin conditioners. Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne. It is used in lubrication and plasticizers.

참고

Store away from strong oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

참조 문헌

M.R. Gasco, et al. In vitro permeation of azelaic acid from viscosized microemulsions.Int. J. Pharm.,1991,69(3), 193-196.

Graupe K, et al. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports.European Pubmed.,1996,57/span>(1), 20-35.

기타 참조

Merck
14,905
바일슈타인
1101094
통합 관세 코드
2917.13
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
CM1980000

권장

최근에 본 것

화학물질

화학물질

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