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N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Edward G. Janzen.; C. Anderson Evans. Rate constants for the addition of phenyl radicals to N-(tert-butyl)-.alpha.-phenylnitrone (spin trapping) and benzene (phenylation) as studied by electron spin resonance. J. Am. Chem. Soc. 1975, 97 (1), 205-206.
Xianghui Cao.; John W. Phillis. α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Research. 1994, 644 (2), 267-272.
For examples of 1,3-dipolar cycloaddition reactions, see N,ɑ-Diphenyl nitrone, L00185.