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503-38-8 - Trichloromethyl chloroformate, 98% - Chloroformic acid trichloromethyl ester - Diphosgene - A17444 - Alfa Aesar

A17444 Trichloromethyl chloroformate, 98%

CAS 번호
503-38-8
동의어
Chloroformic acid trichloromethyl ester
Diphosgene

사이즈 가격 ($) 수량 재고 여부
10g 41.80
50g 161.00
250g 553.00
장바구니에 추가 대량 견적에 추가 항목 보기

Trichloromethyl chloroformate, 98%

MDL
MFCD00015553
EINECS
207-965-9

화학적 특성

화학식
C2Cl4O2
화학 식량
197.83
융점
-57°
비등점
128°
인화점
>110°(230°F)
밀도
1.640
굴절률
1.4570
감도
Moisture Sensitive
용해도
Miscible with ethanol, ether and benzene. Immiscible with water.

용도

Trichloromethyl chloroformate is used as a reagent in the synthesis of organic compounds. It serves as a source of phosgene used in some laboratory preparations. Also, it is used as a reactant for the synthesis of cyclic carbamimidates, N-alkenyl and cycloalkyl carbamates and prostate-specific membrane antigen-targeted anticancer prodrugs. In addition, it is involved in the preparation of an erythromycin A derivatives and antibody-drug conjugates. It is utilized in the conversion of amines, carboxylic acids, formamides in to isocyanates, acid chlorides and isocyanides respectively.

참고

Special handling precautions required. View MSDS prior to purchase. MSDS are available online at www.alfa.comStore in a cool place. Light and heat sensitive. Incompatible with strong oxidizing agents and bases.

참조 문헌

Convenient replacement for phosgene in many reactions, for example:

Conversion of amines to isocyanates: J. Org. Chem., 41, 2070 (1976); Org. Synth. Coll ., 6, 715 (1988). For aliphatic amines, best results were obtained in the presence of the hindered amine 1,8-Bis(dimethyl­amino)­naphthalene, L00313: J. Org. Chem., 61, 3883 (1996).

Dehydration of N-monosubstituted formamides to isocyanides: Angew. Chem. Int. Ed., 16, 259 (1977).

Formation of nitriles from oximes Synthesis, 1037 (1986); or carboxamides: Tetrahedron Lett., 27, 2203 (1986).

See also Triphosgene, A14932, and Oxalyl­ chloride, A18012.

Lezama, J.; Domínguez, R. M.; Chuchani, G. Kinetics of the Gas-Phase Elimination Reaction of Benzyl Chloroformate and Neopentyl Chloroformate. Int. J. Chem. Kinet. 2015, 47 (2), 104-112.

Prousis, K. C.; Markopoulos, J.; Mckee, V.; Igglessi-Markopoulou, O. An efficient synthetic approach towards fully functionalized tetronic acids: the use of 1, 3-dioxolane-2, 4-diones as novel protected-activated synthons of α-hydroxy acids. Tetrahedron 2015, 71 (45), 8637-8648.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H330-H314-H318

Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P280-P303+P361+P353-P305+P351+P338-P304+P340-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER/doctor

기타 참조

Merck
14,3334
바일슈타인
970225
위험 등급
6.1
포장 그룹
I
통합 관세 코드
2915.90
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
LQ7350000

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