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7693-46-1 - 4-Nitrophenyl chloroformate, 97% - Chloroformic acid 4-nitrophenyl ester - A18742 - Alfa Aesar

A18742 4-Nitrophenyl chloroformate, 97%

CAS 번호
7693-46-1
동의어
Chloroformic acid 4-nitrophenyl ester

사이즈 가격 ($) 수량 재고 여부
5g 32.30
25g 88.80
100g 258.00
장바구니에 추가 대량 견적에 추가 항목 보기

4-Nitrophenyl chloroformate, 97%

MDL
MFCD00007321
EINECS
231-706-9

화학적 특성

화학식
C7H4ClNO4
화학 식량
201.57
융점
75-82°
비등점
159-162°/19mm
인화점
>110°(230°F)
감도
Moisture Sensitive
용해도
Soluble in acetone, chloroform, acetone, toluene and benzene.

용도

4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.

참고

Moisture sensitive. Store in a cool place. Incompatible with water, acids, alcohols, ammonia, amines and strong bases.

참조 문헌

Reagent for protection of nucleoside alcohols. The carbonate derivatives readily undergo aqueous hydrolysis in the presence of imidazole: J. Org. Chem., 33, 3699 (1967). For use in the formation of a carbonate linker in an efficient N-terminal attachment methodology for solid phase peptide synthesis, see: Synlett, 1609 (2000).

Sarma, B. K.; Liu, X.; Wu, H.; Gao, Y.; Kodadek, T. Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides. Org. Biomol. Chem. 2015, 13 (1), 59-63.

Lee, N. R.; Zhang, X.; Darna, M.; Dwoskin, L. P.; Zheng, G. Muscarinic acetylcholine receptor binding affinities of pethidine analogs. Bioorg. Med. Chem. Lett. 2015, 25 (22), 5032-5035.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H314-H318-H335

Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. May cause respiratory irritation.

주의 설명서: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
518127
위험 등급
8
포장 그룹
II
통합 관세 코드
2915.90
TSCA(독성물질규제법)"
Yes

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