Binds to the polyamine modulatory site of NMDA Spermidine is used in electroporation during transferring the DNA into the cell under the electrical impulse. It is also used for purification of DNA-binding proteins. It combines with calcium chloride and utilized for the precipitation of DNA onto microprojectiles for bombardment with a gene gun. It plays an important role to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy. It serves as a precursor of spermine and essential for both normal and neoplastic tissue growth.
Pietrocola, F.; Lachkar, S.; Enot, D. P.; Niso-Santano, M.; Bravo-San Pedro, J. M.; Sica, V.; Izzo, V.; Maiuri, M C.; Madeo, F.; Mariño, G.; Kroemer, G. Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 2015, 22 (3), 509-516.
Ibarra, A. A. G.; Wrobel, K.; Escobosa, A. R. C.; Elguera, J. C. T.; Garay-Sevilla, M. E.; Wrobel, K. Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography-electrospray ionization-ion trap tandem mass spectrometry (HPLC-ESI-ITMS/MS). J. Chromatogr. B 2015, 1002, 176-184.
해저드 설명서 (EU): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
주의 설명서: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.