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124-20-9 - Spermidine, 99% - N-(3-Aminopropyl)-1,4-diaminobutane - 1,8-Diamino-4-azaoctane - A19096 - Alfa Aesar

A19096 Spermidine, 99%

CAS 번호
124-20-9
동의어
N-(3-Aminopropyl)-1,4-diaminobutane
1,8-Diamino-4-azaoctane

사이즈 가격 ($) 수량 재고 여부
1g 26.30
5g 77.60
25g 298.00
100g 675.00
장바구니에 추가 대량 견적에 추가 항목 보기

Spermidine, 99%

MDL
MFCD00008229
EINECS
204-689-0

화학적 특성

화학식
H2N(CH2)3NH(CH2)4NH2
화학 식량
145.25
융점
22-25°
비등점
128-130°/14mm
인화점
>110°(230°F)
밀도
0.925
굴절률
1.4790
감도
Air Sensitive
용해도
Miscible with water, ethanol and ether.

용도

Binds to the polyamine modulatory site of NMDA Spermidine is used in electroporation during transferring the DNA into the cell under the electrical impulse. It is also used for purification of DNA-binding proteins. It combines with calcium chloride and utilized for the precipitation of DNA onto microprojectiles for bombardment with a gene gun. It plays an important role to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy. It serves as a precursor of spermine and essential for both normal and neoplastic tissue growth.

참고

Hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.

참조 문헌

Pietrocola, F.; Lachkar, S.; Enot, D. P.; Niso-Santano, M.; Bravo-San Pedro, J. M.; Sica, V.; Izzo, V.; Maiuri, M C.; Madeo, F.; Mariño, G.; Kroemer, G. Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 2015, 22 (3), 509-516.

Ibarra, A. A. G.; Wrobel, K.; Escobosa, A. R. C.; Elguera, J. C. T.; Garay-Sevilla, M. E.; Wrobel, K. Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography-electrospray ionization-ion trap tandem mass spectrometry (HPLC-ESI-ITMS/MS). J. Chromatogr. B 2015, 1002, 176-184.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,8742
바일슈타인
1698591
위험 등급
8
포장 그룹
III
통합 관세 코드
2921.29
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
EJ7000000

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