1,4-Cyclohexanediol, cis + trans, is used as a chemical, organic, pharmaceutical intermediate. It is also used as an important intermediate for manufacturing of anti-Cancer and anti-Infective Drugs - dihydroartemisinin and dihydroartemisitene dimers. It is also used in co polyester resins.
RC Olberg.; H Pines.; VN Ipatieff. The Dehydration of 1, 4-Cyclohexanediol. Synthesis of 1, 4-Epoxycyclohexane1. J. Am. Chem. Soc. 194466 (7), 1096-1099.
H Pines.; TP Kobylinski. Hydrogenolysis of alcohols: IV. Dehydration of cis-and trans-1, 4-cyclohexanediol over nickel-kieselguhr catalyst: Contribution to the mechanism of ether formation. Journal of Catalysis. 197017 (3), 394-396.