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667-27-6 - Ethyl bromodifluoroacetate, 97% - Bromodifluoroacetic acid ethyl ester - B20461 - Alfa Aesar

B20461 Ethyl bromodifluoroacetate, 97%

CAS 번호
667-27-6
동의어
Bromodifluoroacetic acid ethyl ester

사이즈 가격 ($) 수량 재고 여부
1g 19.90
5g 61.80
25g 221.00
장바구니에 추가 대량 견적에 추가 항목 보기

Ethyl bromodifluoroacetate, 97%

MDL
MFCD00042069
EINECS
211-567-0

화학적 특성

화학식
BrCF2CO2CH2CH3
화학 식량
202.99
비등점
112-114°
인화점
21°(69°F)
밀도
1.583
굴절률
1.3880
용해도
Soluble in most organic solvents.

용도

Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents.

참조 문헌

S Marcotte.; X Pannecoucke.; C Feasson. Enantioselective Synthesis of α,α-Difluoro-β-amino Acid and 3,3-Difluoroazetidin-2-one via the Reformatsky-Type Reaction of Ethyl Bromodifluoroacetate with Chiral 1,3-Oxazolidines. J. Org. Chem. 199964 ( 23), 8461-8464.

A Sorochinsky.; N Voloshi.; A Markovsky. Convenient Asymmetric Synthesis of β-Substituted α,α-Difluoro-β-amino Acids via Reformatsky Reaction between Davis' N-Sulfinylimines and Ethyl Bromodifluoroacetate. J. Org. Chem. 200368 ( 19), 7448-7454.

Valuable building block for the introduction of the CF2 group by Reformatsky reaction with aldehydes. A further development of this chemistry involves the generation of an ɑɑ-difluoro-ß-lactone, followed by thermal decarboxylation as a high-yield route to 1,1-difluoroalkenes: J. Org. Chem., 60, 5378 (1995):

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
1906095
위험 등급
3
포장 그룹
II
통합 관세 코드
2915.90
TSCA(독성물질규제법)"
No

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