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It is known to inhibit cell division, and is also used by certain types of bacteria (such as Escherichia coli) as a source of L-Histidine. It can be used in the design of peptide drugs, cationic peptides, such as analogues of carnosine and also be used as a heavy metal sequestration agent.
Rébora K, et al. Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.Genetics.,2005170(1), 61-70.
Calligaro A, et al. Kinetics of D-histidine diffusion across rat intestine in vitro.Archives internationales de physiologie et de biochimie.,1978,86(2), 327-342.