Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

10238-21-8 - Glybenzcyclamide, 99% - Glibenclamide - Glyburide - B21459 - Alfa Aesar

B21459 Glybenzcyclamide, 99%

CAS 번호
10238-21-8
동의어
Glibenclamide
Glyburide

사이즈 가격 ($) 수량 재고 여부
25g 77.20
100g 284.00
장바구니에 추가 대량 견적에 추가 항목 보기

Glybenzcyclamide, 99%

MDL
MFCD00056625
EINECS
233-570-6

화학적 특성

화학식
C23H28ClN3O5S
화학 식량
494.01
융점
171-174°
용해도
Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

용도

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 ?M).

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

참조 문헌

DG Dills.; J Schneider. Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Glimepiride/Glyburide Research Group. Hormone and metabolic research= Hormone. 199628 (9), 426-429.

M Jab?rek.; V Yarov-Yarovoy.; P Paucek. State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate. Hormone and metabolic research= Hormone. 1998273 (9), 13578-13582.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H303

May be harmful if swallowed.

주의 설명서: P312a

Call a POISON CENTER/doctor if you feel unwell.

기타 참조

통합 관세 코드
2935.90
TSCA(독성물질규제법)"
No

권장

  • A10459

    Quinine, anhydrous, 99% (total base), may cont. up to 5% dihydroquinine
  • A10772

    Triethylene glycol, 99%
  • A11165

    Hemin (porcine), 97+%
  • A12559

    (+)-Quinidine
  • A12747

    1,1,1,3,3,3-Hexafluoro-2-propanol, 99+%

최근에 본 것

화학물질

화학물질

금속 및 재료

촉매

분석 기기 및 실험실 용품